ArticleFrontiers in cardiovascular medicine2026
Bridging the post-discharge management gap in venous thromboembolism: linking adherence patterns to persistent hypercoagulability.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This observational study investigates the relationship between post-discharge adherence to venous thromboembolism (VTE) preventive measures (including anticoagulant therapy, compression therapy, and follow-up attendance) and the resolution of hypercoagulability, as assessed through serial D-dimer measurements. It is important to note that clinical recurrence outcomes were not directly measured in this study; the primary endpoint was biomarker trajectory. Methods: Conducted at a tertiary vascular surgery department in Changsha, China, between April and September 2024, this prospective cohort study enrolled 110 patients with confirmed VTE diagnoses. Participants were stratified into three adherence categories based on their post-discharge compliance with prescribed anticoagulation and compression therapies using objective criteria of treatment completion and self-reported behavior: complete adherence (Group A, Results: Only 38.4% of patients maintained consistent use of elastic stockings throughout the 90-day follow-up period, with adherence declining most substantially between 30 and 60 days post-discharge. D-dimer trajectories revealed marked intergroup differences: patients in the non-adherence group demonstrated minimal reduction in D-dimer levels (Δ -0.52 μg/mL; 95% CI: -1.46-0.42), whereas those in the complete adherence group showed substantial decreases (Δ -4.87 μg/mL; 95% CI: -5.92 to -3.82; Conclusion: Our findings establish a direct biological link between the post-discharge "management gap" in VTE care and persistent hypercoagulability. We propose reframing VTE as a chronic high-risk condition necessitating structured long-term management, with particular emphasis on interventions targeting the 60-day transition period and smoking cessation as high-yield strategies. These insights advocate for a paradigm shift from acute treatment to sustained risk control in VTE management.
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