Evidence map›Paper›PMID 41783022›Full record

ArticleFrontiers in cardiovascular medicine2026

The impact of right ventricular lead position on outcomes in cardiac resynchronization therapy patients.

Yanfei Wang, Yan Xiong, Rana Abdul Qadir, Chunchang Qin, Enrun Wang, Guodong Chen, Zhaoyan Li, Lingyu Zhang, Fengpeng Jia, Yijia Tang

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Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yanfei WangDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yan XiongDepartment of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Rana Abdul QadirDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chunchang QinDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Enrun WangDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Guodong ChenDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhaoyan LiDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Lingyu ZhangDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Fengpeng Jia *Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yijia Tang *Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The effect of right ventricular (RV) lead position on the response to cardiac resynchronization therapy (CRT) remains unclear. We evaluated the effects of different RV lead positions on electrophysiology, echocardiography, and clinical outcomes. Methods: This was a retrospective cohort study. A total of 253 patients received CRT with left ventricular (LV) leads implanted in the LV posterolateral coronary vein were included in this study. According to the position of RV lead, the patients were divided into low septal (LSP) group (141 cases), medium septal (MSP) group (36 cases), high septal (HSP) group (32 cases) and left bundle branch area pacing (LBBAP) group (44 cases). The primary endpoint included a composite of rehospitalization for heart failure (HF) and all-cause mortality, assessed using Kaplan-Meier and Cox proportional hazards analyses. Secondary endpoints included changes in CRT response, arrhythmic events, device-related complications, pacing parameters, QRS duration, and echocardiographic parameters at 12-month follow-up. Results: There were no statistically significant differences in baseline characteristics among the four groups. The non-response rate of CRT (defined as failure to achieve an increase in LVEF >10% and an improvement in NYHA class by at least 1 grade) in the LSP group (48.2%) was higher than that in the HSP group (34.4%), MSP group (16.7%) and LBBAP group (18.2%) ( Conclusion: RV middle septum or left bundle branch area pacing may improve electrical synchronization, reverse ventricular remodeling, and reduce the incidence of non-response to CRT and arrhythmia in patients with heart failure receiving CRT.

Indexed as

cardiac resynchronization therapyclinical outcomeefficacyheart failureright ventricular electrode location

Identifiers

PMID41783022
PMCPMC12955608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.