ArticleFrontiers in cardiovascular medicine2026
Nutritional and inflammatory biomarkers predicting hospitalization length in acute decompensated heart failure EF below 50.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Despite evidence on nutritional and inflammatory markers in various conditions, their combined impact on outcomes in acute decompensated heart failure (ADHF) with reduced left ventricular ejection fraction (LVEF <50%) remains underexplored. This study investigated associations between these biomarkers and clinical outcomes in ADHF patients with LVEF <50%. Methods: This retrospective study included 232 patients with ADHF hospitalized between January and December 2024. Patients were grouped by hospitalization length (0-5 vs. > 5 days). Nutritional and inflammatory biomarkers were calculated from admission blood samples and analyzed with demographic and clinical characteristics using appropriate statistical methods. Results: Patients with prolonged hospitalization (>5 days, Conclusion: In ADHF patients with LVEF <50%, poor nutritional status (low HALP and PNI) and high inflammatory burden (elevated SII and SIRI) were linked to prolonged hospitalization. Higher HALP and PNI predicted shorter stays, with PNI showing superior discriminatory power, suggesting nutritional optimization may improve outcomes.
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