Evidence map›Paper›PMID 41782994›Full record

ArticleMaterials today. Bio2026

Ultrasound-activated dual-targeted liposomes for visualized precise neuromodulation against myocardial ischemia-reperfusion injury.

Haoyuan Hu, Weiqin Yao, Huijun Wu, Qian Li, Wei Guo, Yida Pang, Hong Jiang, Yao Sun, Wei-Hai Chen, Songyun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haoyuan HuCardiovascular Hospital, Renmin Hospital of Wuhan University, Cardiac Autonomic Nervous System Research Center of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, 430060, PR China.
Weiqin YaoKey Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, PR China.
Huijun WuCardiovascular Hospital, Renmin Hospital of Wuhan University, Cardiac Autonomic Nervous System Research Center of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, 430060, PR China.
Qian LiKey Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China.
Wei GuoCardiovascular Hospital, Renmin Hospital of Wuhan University, Cardiac Autonomic Nervous System Research Center of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, 430060, PR China.
Yida PangKey Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China.
Hong JiangCardiovascular Hospital, Renmin Hospital of Wuhan University, Cardiac Autonomic Nervous System Research Center of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, 430060, PR China.
Yao SunCollege of Biomedicine and Health, Huazhong Agricultural University, Hubei Jiangxia Laboratory, Wuhan, 430070, PR China.
Wei-Hai ChenKey Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, PR China.
Songyun WangCardiovascular Hospital, Renmin Hospital of Wuhan University, Cardiac Autonomic Nervous System Research Center of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, 430060, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial ischemia-reperfusion (I/R) injury remains a critical clinical challenge with limited effective treatments. Sympathetic hyperactivation and microglia-mediated neuroinflammation in the paraventricular nucleus exacerbate myocardial I/R injury. Whilst previous studies suggest that sonodynamic neuromodulation has the potential to impede neuroinflammation and confer cardioprotective effect, existing sonosensitizers employed in neuromodulation demonstrate deficiencies in terms of cellular targeting specificity and the capacity to facilitate functional imaging of neuroinflammation. Herein, a sonosensitizer (BT) was designed based on a donor-acceptor-donor scaffold exhibiting emission in the near-infrared (NIR)-II window, and it was further engineered into a neuroinflammatory dual-targeted sonosensitizer through antibody-modified liposomes (named BT@Lip-TN).

Indexed as

Dual-targetedImagingLiposomesMyocardial ischemia-reperfusion injuryNeuroinflammationSonosensitizer

Identifiers

PMID41782994
PMCPMC12955659

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.