ArticleMacromolecules2025
Polymer Microstructure Directs the Solvent-Selective Swelling Response of Polymer Brushes.
Article in Macromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Glycosaminoglycan-Inspired Polymer Brushes Promote Human Mesenchymal Stem Cell Proliferation While Retaining Trilineage Differentiation Potential.ACS applied materials & interfaces · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
To exploit polymer brushes' solvent-responsive properties for applications in nanoparticle transport and sensing, we must elucidate how polymer composition and polymer microstructure shape brush swelling in varied solvent environments. We compared the solvent-selective response of block and statistical copolymer brushes of varied solvophobic-to-solvophilic ratios by measuring brush swelling in two solvents of varying polarity. We first copolymerized 2-(dimethylamino)ethyl methacrylate (DMA) and 2-(diisopropylamino)ethyl methacrylate (DiPA) and tuned DMA/DiPA ratios in block and statistical copolymer brushes. Then, we selectively quaternized DMA to enlarge solvophilicity differences between DMA and DiPA:water but not isopropanol is a good solvent for qDMA whereas DiPA exhibits the opposite solvation preference. In water, increasing DiPA incorporation depressed brush swelling for both block and statistical copolymer brushes. However, in isopropanol, swelling responses diverged; block copolymer brushes swelled between 9 and 37% less than compositionally equivalent statistical copolymer brushes. Additionally, we investigated the feasibility of deploying our polymer brushes in cell-interfacing applications by evaluating cytocompatibility. We established that the spatial distribution-and not just the relative abundance of solvophobic and solvophilic repeat units-governs polymer brushes' solvent responsivity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.