ArticleNetwork neuroscience (Cambridge, Mass.)2026
Neural compensation in persons with HIV and marijuana use: Insights from a reorganized DMN.
Article in Network neuroscience (Cambridge, Mass.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The interactive effects of HIV and marijuana (MJ) on the brain remain largely unknown, despite the prevalence of cognitive implications in this population. This study examined the impacts of HIV and MJ on brain networks crucial for normal cognitive function. Functional MRI data and a battery of neuropsychological tests from 237 HIV+ and HIV- adults aged 25-59 years, stratified by MJ use, were collected. The following hypotheses were then tested: (a) HIV is associated with widespread disruption of the small-world organization of the default mode network (DMN) that is exacerbated by MJ use; (b) observed differences are reflected in cognitive performance. Clustering coefficient and global efficiency were used to measure small-world organizations. We found significant differences in the DMN's clustering and efficiency between our control group (HIV-MJ-) and the other three groups (HIV+MJ-, HIV-MJ+, and HIV+MJ+). In those with HIV/MJ, the DMN reorganized toward a network explained by efficiency than clustering. Global cognitive performance was associated with this group difference. Unlike the control group, participants with HIV/MJ showed an integrated DMN across all cognitive scores. The higher integrity of the DMN in patients with HIV and MJ use (particularly when co-occurring) across cognitive scores could imply compensation to preserve cognitive function.
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