Evidence map›Paper›PMID 41782922›Full record

ArticleContemporary clinical trials communications2026

The HEART-GP strategy for ruling out acute coronary syndrome in out-of-hours primary care: a diagnostic accuracy trial protocol.

Indra M B Melessen, Jelle C L Himmelreich, Amy Manten, Edanur Sert, Simone van den Bulk, Tobias N Bonten, Martijn H Rutten, Eric P Moll van Charante, Ralf E Harskamp

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Article in Contemporary clinical trials communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Indra M B MelessenAmsterdam UMC, University of Amsterdam, Academic Medical Center, Department of General Practice, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
Jelle C L HimmelreichAmsterdam UMC, University of Amsterdam, Academic Medical Center, Department of General Practice, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
Amy MantenAmsterdam UMC, University of Amsterdam, Academic Medical Center, Department of General Practice, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
Edanur SertAmsterdam UMC, University of Amsterdam, Academic Medical Center, Department of General Practice, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
Simone van den BulkLeiden University Medical Center, Department of Public Health and Primary Care, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
Tobias N BontenLeiden University Medical Center, Department of Public Health and Primary Care, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
Martijn H RuttenCoöperatie Cohesie, Huisartsenspoedpost Noord-Limburg, Prof. Gelissensingel 20, 5912JX, Venlo, the Netherlands.
Eric P Moll van CharanteAmsterdam UMC, University of Amsterdam, Academic Medical Center, Department of General Practice, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
Ralf E HarskampAmsterdam UMC, University of Amsterdam, Academic Medical Center, Department of General Practice, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute coronary syndrome (ACS) is a life-threatening condition that requires rapid identification to prevent morbidity and mortality. Differentiating ACS from benign conditions remains difficult in out-of-hours primary care (OOH-PC) settings due to non-specific and overlapping symptom profiles, and limited diagnostic resources. Current guidelines promote a low threshold for emergency department (ED) referral. Despite this cautious approach, ACS cases are still missed. The arrival of high-sensitivity troponin (hs-troponin) point-of-care testing (POCT) may enable safer, faster, and more efficient diagnosis. Methods and analysis: This multicenter prospective diagnostic accuracy trial evaluates the Anticipated results: We anticipate that the Ethics: The study was approved by the Medical Research Ethics Committee of the Amsterdam UMC (NL82428.000.22, 02-03-2023) and registered in the ISRCTN-registry (ISRCTN11954040 https://doi.org/10.1186/ISRCTN11954040).

Indexed as

After hours careChest painHs-troponin POCTMajor adverse cardiac eventsPrimary health careRisk stratification scores

Identifiers

PMID41782922
PMCPMC12954503

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.