Evidence map›Paper›PMID 41782886›Full record

ArticleFrontiers in immunology2026

Case Report: A case of superficial spreading malignant melanoma with sentinel lymph node metastasis misdiagnosed as "pigmented nevus".

Xiaolin Bu, Jing Guo, Liwei Feng, Yeqiang Liu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaolin BuDepartment of Dermatology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Jing GuoPostgraduate Training Base at Shanghai Gongli Hospital, Ningxia Medical University, Shanghai, China.
Liwei FengSchool of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, China.
Yeqiang LiuDepartment of Pathology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 45-year-old woman presented with a black hemispherical plaque on her right lower leg that had developed three years ago without an obvious cause. The lesion gradually enlarged without pain or pruritus. After excision, histopathological examination revealed atypical Spitz nevus. At a dermatology specialty hospital, pathological review suggested superficial spreading melanoma. Immunohistochemistry revealed diffusely positivity for S100, Melan-A, Ki-67, P16, Sox-10 and HMB45. Molecular pathological testing revealed mutations in the TERT promoter and BRAF and CDKN2A/B genes. Extended tumor resection with an intraoperative sentinel lymph node biopsy identified SN2/2. Dissection of the right inguinal lymph nodes revealed melanoma metastasis in 10 of 14 lymph nodes, with Immunolohistochemistry showing diffusely positivity for Sox-10 and Melan-A. The final diagnosis was superficially spreading malignant melanoma with regional lymph node metastasis. Postoperative adjuvant therapy included systemic chemotherapy and targeted therapy. No recurrence was observed during the 2-year follow-up period.

Indexed as

MelanomaNevus, Epithelioid and Spindle CellNevus, PigmentedSentinel Lymph NodeSkin NeoplasmsBiomarkers, TumorCutaneous Malignant MelanomaDiagnostic ErrorsFemaleHumansImmunohistochemistryLymphatic MetastasisMiddle AgedProto-Oncogene Proteins B-rafSentinel Lymph Node BiopsyTelomeraseBiomarkers, TumorProto-Oncogene Proteins B-rafTelomeraseatypical Spitz nevuscutaneous malignant melanomaimmunohistochemistrymisdiagnosedmolecular genetic analysis

Identifiers

PMID41782886
PMCPMC12953533

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.