Evidence map›Paper›PMID 41782824›Full record

ArticleiScience2026

Bipolar cell networks underlying steady-state intensity encoding in intrinsically photosensitive retinal ganglion cells.

Shai Sabbah, Carin Papendorp, Inbar Behrendt, Hala Rasras, Jesse Cann, Megan L Leyrer, Elizabeth Koplas, Marjo Beltoja, Cameron Etebari, Ali Noel Gunesch and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shai SabbahDepartment of Medical Neurobiology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Carin PapendorpDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Inbar BehrendtDepartment of Medical Neurobiology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Hala RasrasDepartment of Medical Neurobiology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Jesse CannDepartment of Medical Neurobiology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Megan L LeyrerDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Elizabeth KoplasDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Marjo BeltojaDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Cameron EtebariDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Ali Noel GuneschDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Luis CarreteDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Min Tae KimDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Gabrielle ManoffDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Ananya Bhatia-LinDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Tiffany ZhaoDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Henry DowlingDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Kevin L BriggmanCenter of Advanced European Studies and Research (Caesar), Max Planck Institute, 53175 Bonn, Germany.
David M BersonDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrinsically photosensitive retinal ganglion cells (ipRGCs) encode ambient light intensity at steady-state and drive physiology even in the absence of melanopsin, but the synaptic basis of such encoding remains unclear. Using ultrastructural reconstructions, we mapped specific bipolar cell (BC) types and synapses conveying photoreceptor input to ipRGCs. Functional imaging showed BC glutamate release onto ipRGCs encodes intensity at steady-state, though release onto other RGCs also exhibits such encoding. Disrupting inhibition on BCs spared intensity-encoding release at ipRGC strata but reduced it elsewhere, consistent with inhibition shifting BC dynamic range. Recording postsynaptic excitatory currents showed that ipRGCs better preserve BC-derived intensity encoding than conventional RGCs. Thus, ipRGCs receive excitation from selected, inhibition-resistant BCs whose steady-state release encodes intensity. This, together with the enhanced preservation of postsynaptic intensity encoding, ensures reliable ipRGC intensity signaling independent of visual contrast to drive physiology and behavior.

Indexed as

cellular neuroscienceneurosciencesensory neuroscience

Identifiers

PMID41782824
PMCPMC12955654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.