ArticleiScience2026
Single-cell aging trajectories reveal a dynamic coupling between nuclear size and proteasome concentration.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Cell enlargement drives aging-associated proteome remodeling and shortens replicative lifespan.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Yeast replicative aging is cell autonomous and thus a good model for mechanistic study from a dynamic systems perspective. Utilizing an engineered strain and a high-throughput microfluidic device, we analyzed the dynamic trajectories of thousands of single yeast mother cells throughout their lifespan, using fluorescent reporters that cover a wide range of biological processes. We found that proteostasis markers are the strongest predictors of the lifespan of individual cells. We observed that proteasome concentration in the nucleus shows dynamics distinct from those in the cytoplasm, with much more rapid decrease during aging; such behavior can be accounted for by the increase of nuclear size in a simple mathematical model of transport. We hypothesize that nuclear enlargement may dilute key nuclear factors, potentially contributing to aging. Our large-scale single-cell dynamics dataset provides a valuable resource for analyzing relationships among aging hallmarks.
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Registered trials
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