ArticleCureus2026
Predictive Accuracy of Cord Blood C-reactive Protein and Immature-to-Total Neutrophil Ratio for Early-Onset Neonatal Sepsis in High-Risk Deliveries: A Prospective Observational Study at a Tertiary Care Center in Central India.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background Early-onset neonatal sepsis (EOS) remains a critical contributor to neonatal mortality, particularly in low- and middle-income countries like India. Blood culture, while considered the diagnostic gold standard, is often limited by low sensitivity and delayed results. Cord blood biomarkers such as C-reactive protein (CRP) and the immature-to-total neutrophil ratio (I/T) offer promising alternatives for early, non-invasive detection of EOS. Methods This prospective observational study was conducted at a tertiary-care teaching hospital in Central India between June 2023 and December 2024. A total of 170 neonates born to mothers with one or more risk factors for EOS were enrolled. Umbilical cord blood and peripheral venous blood were analyzed for CRP, I/T ratio, complete blood count (CBC), and culture. Receiver operating characteristic (ROC) analysis was used to determine diagnostic performance and optimal cutoff values. Results Cord blood culture was positive in 25.9% of cases, with coagulase-negative
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