Evidence map›Paper›PMID 41782749›Full record

ArticleNational science review2026

Cobalt-catalyzed alkyne silylamidation unlocks

Jixin Wang, Ting Zeng, Kaixin Chen, Zexu Chen, Long Lin, Wenhua Yu, Jianlin Yao, Hong Yi, Baosheng Wei, Jie Li

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In one paragraph

Article in National science review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jixin WangState Key Laboratory of Bioinspired Interfacial Materials Science, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Ting ZengState Key Laboratory of Bioinspired Interfacial Materials Science, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Kaixin ChenCollege of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, China.
Zexu ChenState Key Laboratory of Bioinspired Interfacial Materials Science, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Long LinState Key Laboratory of Bioinspired Interfacial Materials Science, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Wenhua YuCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
Jianlin YaoState Key Laboratory of Bioinspired Interfacial Materials Science, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Hong YiCollege of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, China.
Baosheng WeiCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.ORCID https://orcid.org/0000-0002-2708-2435
Jie LiState Key Laboratory of Bioinspired Interfacial Materials Science, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.ORCID https://orcid.org/0000-0002-6912-3346

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to their unique conformational properties and activities, dehydropeptides play a pivotal role in the fields of biological and medicinal chemistry. Yet, the synthesis of unnatural dehydropeptides still suffers from cumbersome steps and less generality, in particular, with rather limited structural diversity. Herein, a modular cobalt-catalyzed 1,2-silylamidation of non-conjugated alkynes with dioxazolones and silylzinc pivalates is disclosed, thus affording structurally diverse non-canonical sila-dehydropeptides with complete control of regio- and stereoselectivity. Notably, the reaction enables efficient peptide ligation between peptide-containing dioxazolones and peptide-containing alkynes in a

Indexed as

alkynescobalt catalysisdehydropeptidessilylamidationstereoselectivity

Identifiers

PMID41782749
PMCPMC12954855

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.