ArticleInternational journal of reproductive biomedicine2025
Integrative RNA-seq analysis reveals immune-related hub genes
Article in International journal of reproductive biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Recurrent spontaneous abortion (RSA) impacts 1-5% of women of reproductive age, constituting a significant health issue. Despite advances in our understanding of RSA, the fundamental molecular mechanisms remain inadequately defined. Examining differentially expressed genes (DEGs) in RSA may yield essential insights into the disease's pathophysiology and enable the identification of novel ameliorative targets. Objective: This study aimed to identify key DEGs, elucidate their interaction networks, and uncover potential hub regulators across decidua and villus tissues in RSA vs. control samples. Materials and Methods: In this bioinformatics study, we analyzed RNA-seq datasets GSE113790 (decidua) and GSE121950 (villus) from the gene expression omnibus database using illumina-aligned count matrices. Rigorous batch correction was performed using surrogate variable analysis, followed by differential expression analysis in DESeq2 with thresholds of |log₂FC| Results: After correction and integration, 114 protein-coding DEGs (30 upregulated and 84 downregulated) were identified. The protein-protein interaction network (101 nodes, 116 edges) was significantly enriched over random expectation (p Conclusion: Our integrative approach delineates immune-centric molecular dysfunction in RSA and highlights
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