ArticleInternational journal of reproductive biomedicine2025
An experimental study on shrimp bioactive peptides restoring testicular function in a rat model of fatty liver disease via autophagy, redox balance, and energy transporters.
Article in International journal of reproductive biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Non-alcoholic fatty liver disease is a widely prevalent condition in the modern era, with potential adverse effects on fertility and the reproductive system. Objective: This experimental study investigated the adverse effects of non-alcoholic fatty liver disease induced by a high-fat diet (HFD) on testicular structural integrity, with a focus on oxidative stress and metabolic alterations. Materials and Methods: To produce bioactive peptides (HPs), whiteleg shrimp by-products were hydrolyzed using alcalase at 50 C for 3 hr. For this experimental study, 24 male Wistar rats (230 Results: After 70 days, the HFD group showed higher malondialdehyde and glutathione, but a lower glutathione/glutathione disulfide ratio (40%, p Conclusion: HPs improved tubular differential index and spermiogenesis index values associated with restored GLUT-1/3 and monocarboxylate transporter 4 expression in Sertoli cells, suggesting that Sertoli cells provided enhanced metabolic support for germ cell development.
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