Evidence map›Paper›PMID 41782673›Full record

ArticleACG case reports journal2026

Acquired Immunodeficiency in Newborn Following Intrauterine Exposure to Thiopurines for Treatment of Inflammatory Bowel Disease.

Susan Morand, Michael T Lam, Surachai Amornsawadwattana, Alexandra Gutierrez, Alan A Nguyen, Susan Prockop, Julie Ruggiero, Maleewan Kitcharoensakkul

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Susan MorandDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO.
Michael T LamDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Surachai AmornsawadwattanaDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Alexandra GutierrezDivision of Gastroenterology, Columbia University Irving Medical Center, New York, NY.
Alan A NguyenDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Susan ProckopDepartment of Pediatrics, Boston Children's Hospital-Dana Farber Cancer Institute, Boston, MA.
Julie RuggieroDepartment of Pediatrics, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Maleewan KitcharoensakkulDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thiopurine-based therapy is a common immunosuppressive treatment of inflammatory bowel diseases. It inhibits purine synthesis, and its metabolism is influenced by genetic variation. Thiopurines, azathioprine and 6-mercaptopurine (6-MP), have not been identified as teratogenic in humans and are considered safe to use during pregnancy. Here, we present 3 infants who developed severe lymphopenia secondary to prenatal exposure. Clinicians should be aware of this uncommon but potentially severe side effects.

Indexed as

immunodeficiencyinflammatory bowel diseasepregnancythiopurines

Identifiers

PMID41782673
PMCPMC12956204

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.