Evidence map›Paper›PMID 41782509›Full record

ArticleHistology and histopathology2026

Mechanism and experimental validation of a network pharmacology-based approach of Huoluo Yinao formula in treating chronic cerebral hypoperfusion.

Song Yang, Junpeng Li, Wen Nie, Sen Chen, Haitao Song, Dewen Song, Bo Zhao

Abstract read
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In one paragraph

Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Song YangDepartment of Neurosurgery, Jiaozhou Branch, East Hospital Affiliated to Tongji University, Qingdao, Shandong, PR China.
Junpeng LiDepartment of Neurosurgery, Jiaozhou Branch, East Hospital Affiliated to Tongji University, Qingdao, Shandong, PR China.
Wen NieDepartment of Neurosurgery, Jiaozhou Branch, East Hospital Affiliated to Tongji University, Qingdao, Shandong, PR China.
Sen ChenDepartment of Neurosurgery, Jiaozhou Branch, East Hospital Affiliated to Tongji University, Qingdao, Shandong, PR China.
Haitao SongDepartment of Neurosurgery, Jiaozhou Branch, East Hospital Affiliated to Tongji University, Qingdao, Shandong, PR China.
Dewen SongDepartment of Neurosurgery, Jiaozhou Branch, East Hospital Affiliated to Tongji University, Qingdao, Shandong, PR China.
Bo ZhaoDepartment of Neurosurgery, Jiaozhou Branch, East Hospital Affiliated to Tongji University, Qingdao, Shandong, PR China. zhbctm@163.com.

Funding

Qingdao Medical and Health Research Guiding Project 2023-WJZD048Qingdao Traditional Chinese Medicine Science and Technology Key Project 2023-zyyz09
6 · The paper itself

Abstract

Chronic cerebral hypoperfusion (CCH) is a cerebral dysfunction caused by insufficient cerebral perfusion, and Huoluo Yinao (HLYN) formula is a traditional Chinese medicinal formula used for CCH treatment. We investigated the specific mechanism of HLYN formula on CCH through network pharmacological analysis and

Indexed as

Brain IschemiaDrugs, Chinese HerbalNetwork PharmacologyNeuroprotective AgentsAnimalsChronic DiseaseDisease Models, AnimalHippocampusMaleOxidative StressRatsRats, WistarDrugs, Chinese HerbalNeuroprotective Agents

Identifiers

PMID41782509

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.