Evidence map›Paper›PMID 41782465›Full record

ArticleBrain and behavior2026

Neuropsychiatric Disorders and Constipation: Unraveling Causal Links Through Genetic Analysis.

Guojie Zhao, Haixia Ren, Yi Zhang, Zhi Wang, Qiao Yang, Shuang Liu, Minzhen Li, Zhiyu Xiang, Jingwen Liu

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Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Guojie ZhaoDepartment of Neurosurgery, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Haixia RenDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Yi ZhangDepartment of Neurosurgery, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Zhi WangDepartment of Neurosurgery, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Qiao YangDepartment of Neurosurgery, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Shuang LiuSichuan Provincial Center For Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Minzhen LiSichuan Provincial Center For Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Zhiyu XiangSichuan Provincial Center For Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Jingwen LiuSichuan Provincial Center For Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

National Nature and Science Youth Fund of China 82200598the National Nature and Science Youth Fund of China
6 · The paper itself

Abstract

backgroundNumerous observational studies have suggested a relationship between neuropsychiatric disorders and constipation. However, the specific causal relationships remain unclear. Mendelian randomization (MR) serves as a proven strategy for examining the causal relationships between genetic exposures and outcomes. In the present study, we used a two-sample Mendelian randomization (TSMR) analysis to thoroughly explore the potential bidirectional genetic causal effects between neuropsychiatric disorders and constipation.

methodsWe utilized the R11 data from Finnish genome-wide association studies (GWAS) to examine the association between twelve common neuropsychiatric disorders and constipation using TSMR analysis. To establish this causal link, we applied the random-effects inverse variance weighting (IVW) method. Additionally, we conducted various sensitivity analyses, including MR-Egger analysis, weighted median analysis, and leave-one-out analysis, followed by heterogeneity testing. Finally, reverse MR testing was performed to further elucidate the potential causal relationship between constipation and neuropsychiatric disorders.

resultsThe forward MR results indicated that anxiety (IVW OR = 1.133; 95% CI: 1.021-1.258; p = 0.020) and depression (IVW OR = 1.149; 95% CI: 1.071-1.232; p = 0.000) may increase the risk of constipation. Reverse MR testing further confirmed that constipation increased the risk of anxiety (IVW OR = 1.273; 95% CI: 1.116-1.452; p = 0.000) and depression (IVW OR = 1.207; 95% CI: 1.095-1.331; p = 0.000) and was positively correlated with epilepsy (IVW OR = 1.331; 95% CI: 1.103-1.607; p = 0.003) and trigeminal neuralgia (IVW OR = 1.897; 95% CI: 1.225-2.936; p = 0.004). No pleiotropy or heterogeneity was observed in the MR analysis.

conclusionOur research elucidates the underlying bidirectional causal relationship between twelve common neuropsychiatric disorders and constipation. These findings emphasize the importance for clinical practitioners to prioritize the identification and management of constipation symptoms in patients with neuropsychiatric conditions, aiming to enhance their overall health and quality of life.

Indexed as

ConstipationMental DisordersFinlandGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization Analysiscausal relationshipsconstipationMendelian randomizationneuropsychiatric disorders

Identifiers

PMID41782465
PMCPMC12961347

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