SynthesisAnnals of the Royal College of Surgeons of England2026
Outcomes for congenitally corrected transposition of great arteries using various surgical techniques: a systematic review and network meta-analysis.
Synthesis in Annals of the Royal College of Surgeons of England, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionCongenitally corrected transposition of the great arteries (ccTGA) is a rare disorder. Here, we evaluated the effectiveness of physiological, anatomical and Fontan repair techniques for ccTGA.
methodsA systematic database search in PubMed, Embase and Cochrane Central Register of Controlled Trials was conducted from inception to 5 June 2023. Random-effects network meta-analysis was performed, comparing mortality, postoperative arrhythmias, reintervention after definitive surgery and transplant-free survival in patients undergoing physiological, anatomical and Fontan repair.
findingsA total of 1,209 patients were included from nine studies. Fontan repair was associated with a higher rate of transplant-free survival (absolute risk [AR] 0.999 (±0.0101), 95% confidence interval [CI]) and reintervention after definitive surgery (AR 0.098 (±0.067), 95% CI), whereas the difference for mortality and postoperative arrhythmias did not reach statistical significance.
conclusionsFontan repair is significantly better than anatomical or physiological repair in terms of transplant-free survival and also had a better rank probability for overall survival and reintervention after definitive surgery.
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