Evidence map›Paper›PMID 41782448›Full record

ArticleJournal of periodontal research2026

MMP-8 in Peri-Implantitis: A Cross-Sectional Study on Genetic Polymorphisms and Enzymatic Activation.

Ioannis Fragkioudakis, Christine Kottaridi, Michalis Paraskeva, Dimitra Sakellari

Abstract read
In one paragraph

Article in Journal of periodontal research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ioannis FragkioudakisDepartment of Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID https://orcid.org/0000-0002-2156-0686
Christine KottaridiDepartment of Genetics, Development, and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID https://orcid.org/0000-0003-0979-3871
Michalis ParaskevaDepartment of Genetics, Development, and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID https://orcid.org/0009-0006-9508-0737
Dimitra SakellariDepartment of Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID https://orcid.org/0000-0002-4365-8406

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This graphical abstract illustrates a molecular cascade linking MMP-8 gene polymorphism (-799C/T), upregulated mRNA expression in peri-implant crevicular fluid, and elevated active MMP-8 protein levels. These factors were independently associated with peri-implantitis and may support molecular-based diagnostics.

Indexed as

Matrix Metalloproteinase 8Peri-ImplantitisPolymorphism, GeneticPolymorphism, Single NucleotideCross-Sectional StudiesCytosineEnzyme ActivationGingival Crevicular FluidHumansRNA, MessengerCytosineMatrix Metalloproteinase 8RNA, MessengeraMMP‐8gene expressionMMP‐8peri‐implantitissingle nucleotide polymorphism

Identifiers

PMID41782448
PMCPMC12961359

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.