Evidence map›Paper›PMID 41782426›Full record

ArticleActa biochimica et biophysica Sinica2026

Luteolin reprograms macrophage polarization via the STING-TBK1 pathway to accelerate bone repair.

Dinglei Zhang, Yilun Wang, Lili Luo, Huihui Bian, Zhimin Gao, Yinghua Li, Tianlong Zhang, Li Su, Hongli Liao, Ying Liu and 1 more

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Article in Acta biochimica et biophysica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Dinglei ZhangShanghai Baoshan Luodian Hospital, School of Medicine, Shanghai University, Shanghai 201908, China.
Yilun WangShanghai Baoshan Luodian Hospital, School of Medicine, Shanghai University, Shanghai 201908, China.
Lili LuoDepartment of Orthopedics, Changzhou Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Changzhou 213003, China.
Huihui BianShanghai Baoshan Luodian Hospital, School of Medicine, Shanghai University, Shanghai 201908, China.
Zhimin GaoDepartment of Orthopedics, Nanning Hospital of Traditional Chinese Medicine, Nanning 530001, China.
Yinghua LiShanghai Baoshan Luodian Hospital, School of Medicine, Shanghai University, Shanghai 201908, China.
Tianlong ZhangShanghai Baoshan Luodian Hospital, School of Medicine, Shanghai University, Shanghai 201908, China.
Li SuShanghai Baoshan Luodian Hospital, School of Medicine, Shanghai University, Shanghai 201908, China.
Hongli LiaoSchool of Pharmacy, Chengdu Medical College, Chengdu 610083, China.
Ying LiuShanghai Baoshan Luodian Hospital, School of Medicine, Shanghai University, Shanghai 201908, China.
Yi LiangDepartment of Orthopedics, Nanning Hospital of Traditional Chinese Medicine, Nanning 530001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages play a pivotal role in bone regeneration, making their polarization a key target for immune regulation and therapeutic intervention. Modulating macrophage polarization represents a promising strategy for enhancing bone repair. Luteolin, a plant-derived flavonoid with well-documented anti-inflammatory properties, has been explored for its role in bone repair. However, its specific effects on macrophage polarization in bone repair remain unclear. This study investigates the role of luteolin in macrophage polarization and its underlying mechanisms. Our findings demonstrate that luteolin promotes M2 polarization while suppressing M1 polarization, as indicated by a reduction in the expression of pro-inflammatory markers, including IL-6 and iNOS, and an increase in the expression of anti-inflammatory factors, such as CD206, IL-10, and TGF-β. Mechanistically, luteolin inhibits STING oligomerization, thereby suppressing the STING-TBK1 pathway and mitigating downstream inflammatory responses.

Indexed as

bone regenerationimmunomodulationluteolinmacrophage reprogrammingSTING-TBK1

Identifiers

PMID41782426
PMCPMC13191478

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.