ArticlePediatrics international : official journal of the Japan Pediatric Society
Age-related variations in prostaglandin E-major urinary metabolite values in Japanese children.
Article in Pediatrics international : official journal of the Japan Pediatric Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProstaglandin E-major urinary metabolite (PGE-MUM) is an emerging noninvasive biomarker used to evaluate clinical and endoscopic activity in patients with inflammatory bowel disease. Previous studies have shown that PGE-MUM values correlate with colonic inflammation in pediatric ulcerative colitis; however, reference values for children without inflammation have not been defined yet. This study aimed to determine the normal reference values of PGE-MUM in healthy pediatric subjects without inflammatory conditions.
methodsBetween December 2018 and January 2022, we prospectively enrolled 221 participants (cross-sectional study, aged 0-15 years) who were undergoing growth hormone stimulation testing for diagnostic purposes and exhibited no symptoms of inflammation or elevated C-reactive protein levels at a single pediatric center in Japan. PGE-MUM values were measured using a chemiluminescent enzyme immunoassay and assessed for age- and sex-related differences.
resultsA total of 218 participants were included in the analysis. Based on age, the participants were classified as young children (2-6 years, n = 147) and older children (7-14 years, n = 66); the reference ranges for the two groups were identified as 18.4-58.7 μg/g·Cr and 12.4-50.3 μg/g·Cr, respectively. The PGE-MUM values tended to decrease with increasing age; however, no significant sex-related differences were observed (median 29.1 μg/g·Cr for boys versus 30.4 μg/g·Cr for girls).
conclusionsHealthy pediatric subjects generally have higher PGE-MUM values than healthy adults, with particularly elevated values in young children (2-6 years). These observations suggest that age-related variability must be taken into account when using PGE-MUM as a biomarker in young children with ulcerative colitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.