Evidence map›Paper›PMID 41782125›Full record

ArticleJournal of cannabis research2026

The power of zinc: excess and deficiency of Zn decrease cannabinoids in cannabis without Zn toxicity concerns to consumers.

Sivan Shiponi, Nirit Bernstein

Abstract read
In one paragraph

Article in Journal of cannabis research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cannabidiol-DominantNutrients · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sivan ShiponiInstitute of Soil Water and Environmental Sciences, Volcani Institute, 68 HaMaccabim Road, P.O.B 15159, Rishon LeZion, 7505101, Israel.
Nirit BernsteinInstitute of Soil Water and Environmental Sciences, Volcani Institute, 68 HaMaccabim Road, P.O.B 15159, Rishon LeZion, 7505101, Israel. Nirit@agri.gov.il.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSome of the mineral nutrients essential for plants are heavy metals, which their consumption may involve health concerns to the consumers. Hence, for safe consumption, optimized fertilization protocol for cannabis plants needs to focus also on minimizing the accumulation of potentially toxic minerals in the inflorescences. Zinc is an essential microelement for plants that has a toxic effect on the human body when consume in high concentration. The present study aimed to understand the drug-type (medical) cannabis plant response to Zn supply, for identifying the optimal Zn supply that balance high quality production with safe product.

methodscannabis plants were grown under five Zn levels (0.05, 0.1, 0.35, 1.0, 4.0 mg L− 1) in controlled environment; and morpho-physiology analyses, cannabinoid profile, and ionome-profiling in the plant-organs were conducted.

resultsIncreased level of Zn supply reduced the relative accumulation of Zn in the inflorescences, and excess Zn was stored in the plant root, and therefore does not impose additional health risk to consumers. Cannabinoid concentrations were highest under 0.35 mgL− 1 Zn supply, and decreased with further increase in Zn supply. The acidic cannabinoids THCA, CBDA, CBCA, CBDVA, THCVA increased with the increase in Zn supply up to 0.1–0.35 mgL− 1 and declined with further increase in Zn. Zn deficiency (under 0.05 mgL− 1 Zn supply) reduced physiological performance, plant growth and inflorescence yield, and stimulated uptake of Zn, P, S, Ca, Fe, and Mn. Symptoms of excess Zn were death of leaf tips; however plant performance was overall not affected by Zn excess.

conclusionsExcess Zn is retained in the root and excluded from the inflorescence, thereby not imposing health risk to the consumers. The recommended Zn concentration in the fertigation solution that was found to attain highest specialized-metabolite concentrations, and optimal yield and plant performance is 0.35 mgL− 1.

Identifiers

PMID41782125
PMCPMC12961903

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.