Trial reportBMC oral health2026
Oral probiotic Weissella cibaria improves halitosis and reduces periodontal pathogens: a randomized, double-blind, placebo-controlled trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A Chewing Gum ContainingNutrients · 2026Trial
- Association between perceived stress and self-reported halitosis among university students: the mediating role of xerostomia, a cross-sectional study.BMC oral health · 2026Article
- The subgingival microbiome in periodontitis: from ecological dysbiosis and metabolic reprogramming to precision interventions.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundHalitosis is closely linked to periodontal inflammation and affects oral health–related quality of life. This randomized trial investigated the effects of Weissella cibaria CMU (OraCMU) on halitosis in adults with gingivitis and early (Stage I–II) periodontitis.
methodsEighty adults were enrolled in a randomized, double-blind, placebo-controlled trial and assigned to OraCMU (n = 40) or placebo (n = 40). Participants consumed two slow-dissolving tablets daily for 8 weeks. The primary endpoint was change in total Volatile sulfur compounds (VSCs) from baseline to week 8. Secondary outcomes included organoleptic test (OLT), bad breath improvement (BBI), gingival index (GI), bleeding on probing (BOP), probing depth, plaque index, and oral health impact profile-14 (OHIP-14). Multiplex quantitative real-time PCR was performed at baseline and week 8 to quantify nine periodontopathogens and to derive the periodontal pathogen index (PPI) and PPI level.
resultsThe OraCMU group showed a significantly greater reduction in total VSC (primary endpoint) at week 8 than the placebo group (P = 0.001). Secondary outcomes favored OraCMU for OLT (P = 0.015) and BBI (P = 0.045). Periodontal indices (GI and BOP) improved more in the OraCMU group at week 8 (P = 0.0035 and P = 0.030, respectively). qPCR showed lower levels of Porphyromonas gingivalis, Prevotella intermedia, and Treponema denticola in the OraCMU group at week 8 (P = 0.001, P = 0.046, and P = 0.005), along with lower PPI and PPI level (P = 0.005 and P = 0.002). OHIP-14 improved within the OraCMU group (P < 0.05) but did not differ between groups (P > 0.05).
conclusionsEight-weeks of W. cibaria CMU supplementation reduced major halitosis indices and improved periodontal pathogen levels in adults with gingivitis/incipient periodontitis. Longer-term studies, including post-intervention follow-up, are needed to assess the sustainability of the effects.
trial registrationClinical Research Information Service (CRIS), KCT0009810, registered 27 September 2024, retrospectively registered.
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