ReviewJournal of neuroinflammation2026
Spatiotemporal dynamics of brain pericytes in ischemic stroke.
Review in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Injectable microsphere-based delivery strategies for stem cells and their derivatives in tissue regeneration.Bioactive materials · 2026Review
- KLF2 Is Associated with ERK1/2-MAP2 Activation and Neuron-like Phenotypic Remodeling of PDGFR-β-Lineage Cells Following Ischemic Stroke.Brain sciences · 2026Article
- Inflammation-centered neurovascular-immune-metabolic remodeling in ischemic stroke: stage-dependent mechanisms, regulated cell death, and therapeutic translation.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Pericytes constitute a vital component of the neurovascular unit (NVU) and play a pivotal role in the pathophysiology of ischemic stroke (IS). They perform a variety of critical functions, involving regulating cerebral blood flow (CBF), modulating inflammatory responses, exhibiting stem cell-like properties, and maintaining the integrity of the blood-brain barrier (BBB). During the hyperacute and acute phases of IS, pericytes undergo contraction, contributing to the no-reflow phenomenon (NRP) and compromising BBB integrity. Concurrently, their activation exacerbates neuroinflammation and secondary injury. In contrast, the subacute and chronic phases are characterized by pericyte-mediated reparative processes, including angiogenesis, vascular stabilization, immune modulation, and scar formation. Notably, distinct pericyte subpopulations residing within specific vascular segments, pre-capillary, capillary, and post-capillary, demonstrate unique spatial and temporal functional patterns within the infarct core, penumbra, and peri-infarct regions. By examining these multifaceted dynamics, this review also highlights the intricate characteristics of pericytes as a therapeutic target and investigates novel therapeutic approaches based on their spatiotemporal functional modulation, with the goals of improving microcirculatory disorders, protecting the BBB, decreasing inflammation, and promoting neural repairs.
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Registered trials
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