Evidence map›Paper›PMID 41782023›Full record

ArticleMicrobiome2026

Impacts of host genetics on gut microbiome composition in Alzheimer's disease.

Jinxin Liu, Jixin Cao, Longhao Jia, Ziquan Gan, Xingzhong Zhao, Anyi Yang, Senying Lai, Feng Chen, Yucheng T Yang, Xing-Ming Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinxin LiuDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
Jixin CaoInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.
Longhao JiaInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.
Ziquan GanInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.
Xingzhong ZhaoInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.
Anyi YangInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.
Senying LaiInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.
Feng ChenDepartment of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, 570100, China.
Yucheng T YangHuzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, 313000, China. yangyy@fudan.edu.cn.
Xing-Ming ZhaoDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200433, China. xmzhao@fudan.edu.cn.

Funding

Key Science and Technology Project of Hainan Province ZDYF2024SHFZ058Major Project of Guangzhou National Laboratory GZNL2024A01003National Key R&D Program of China 2023YFF1204800National Natural Science Foundation of China T2225015Shanghai Municipal Education Commission 24KXZNA11Shanghai Science and Technology Commission Program 23JS1410100Shanghai Science and Technology Commission Program 24JS2810100
6 · The paper itself

Abstract

backgroundHost-microbiome interactions play essential roles in the development of Alzheimer's disease (AD), yet the host genetic impacts on gut microbial alterations in AD remain poorly understood.

resultsHere, we simultaneously profiled host genotype and gut microbiome in 252 Chinese individuals with varying degrees of cognitive disability. Using the latent Dirichlet allocation topic model, we identified the Anaerostipes-enriched enterosignature (ES-Ana) at the microbial subgroup level as significantly negatively associated with cognitive disability, which could be recapitulated in external cohorts. With the whole-genome sequencing data, we performed microbiome genome-wide association studies for the ES-Ana relative abundance. We prioritized 41 lead genetic variants and confirmed that the high ES-Ana relative abundance showed a negative correlation with the polygenic risk score of AD, indicating its protective effect against AD. Furthermore, we identified 174 ES-Ana-associated genes, which are enriched in AD-related biological functions and phenotypes, and exhibite pervasive underexpression in glial cells during brain aging.

conclusionsIn summary, our study reveals the complex genetic effects on the gut microbiota in AD, and provides novel evidence for the roles of the gut-brain axis in AD. Video Abstract.

Indexed as

Alzheimer DiseaseBacteriaGastrointestinal MicrobiomeHost Microbial InteractionsAgedFemaleGenetic Risk ScoreGenome-Wide Association StudyGenotypeHumansMaleWhole Genome SequencingAlzheimer’s diseaseGenetic variationMendelian randomizationMicrobiomePolygenic risk scores

Identifiers

PMID41782023
PMCPMC13069797

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.