ReviewCell communication and signaling : CCS2026
Dying cells as architects of the stem cell niche: a conserved mechanism driving tissue regeneration and tumor therapy resistance.
Review in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The stem cell niche plays a pivotal non–cell-autonomous role in maintaining stem cell function, yet it can be disrupted by tissue injury or cancer therapy. Here, we propose that dying cells induced by external insults actively construct a novel, enhanced stem cell niche that facilitates stem cell survival under harsh conditions. This phenomenon is evolutionarily conserved across diverse species and evolutionary hierarchies, contributing critically to both tissue regeneration and tumor recurrence. In the context of tissue regeneration, dying differentiated daughter cells reinforce stemness by secreting ligands and protective factors that support self-renewal. Additionally, damaged environmental cells, including stromal and inflammatory cells, contribute to niche reconstruction through paracrine signaling. The clearance of dying cells further modulates the niche to better support stem cell for regeneration or tumor regrowth. Among cell death modalities, apoptosis, particularly caspase-3–mediated apoptosis, plays a central role by orchestrating microenvironmental remodeling and activating pro-stemness signaling pathways. These mechanisms are also hijacked by cancer cells to reinforce therapy resistance, which are often overlooked. Unraveling how dying cells dynamically reshape the stem cell niche provides novel insights into regenerative biology and may inform therapeutic strategies to overcome tumor therapy resistance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.