Trial reportBMC pediatrics2026
Efficacy of clonidine and melatonin for treating insomnia in anxious children: a randomized comparison.
Trial report in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Current and Emerging Therapies for Pediatric Sleep Disorders: A Narrative Review.Neurology and therapy · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundClonidine and melatonin are two medications that are used off-label in the management of sleep disorders in children. However, there is currently no well-established and effective treatment for sleep disturbances among pediatric patients with anxiety disorders. MATERIALS AND
methodsIn this study, 72 children aged 6 to 12 years diagnosed with anxiety disorders and suffering from insomnia who attended the Farshchian Hospital Clinic in Hamadan between October 2022 and July 2023 were enrolled. Participants were randomly assigned, using simple randomization, into three groups of 24 each to receive clonidine, melatonin, or placebo. Sleep quality was assessed using the Children’s Sleep Habits Questionnaire (CSHQ) at baseline, week 4, and week 6. Both participants and investigators were blinded to the treatment allocation. This study registered with the Iranian Clinical Trials Registry (IRCT20220820055756N1, registered October 16, 2022).
resultsAll 72 participants completed the study. Children receiving clonidine or melatonin showed significant improvement in sleep habits compared with the placebo group at the end of six weeks (P < 0.001). However, there was no significant difference between clonidine and melatonin in terms of sleep quality improvement at week six (P = 0.267). Notably, the incidence of adverse effects did not differ significantly among the three groups.
conclusionThe findings of the present study indicate that both clonidine and melatonin are effective treatments for sleep disturbances in children with anxiety disorders.
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Registered trials
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