Evidence map›Paper›PMID 41781897›Full record

ArticleBMC infectious diseases2026

Epidemiological investigation of an acute gastroenteritis outbreak associated with norovirus GΙΙ.17[P17] in a cross-border travel group - Shanghai Port, China, 2024.

Danlei Liu, Shiwei Yu, Xiangting Tian, Zhiyi Wang, Ye Lu, Yue Dai, Chunli Hu, Xinyi Ma, Mao Mao, Liming Xue and 6 more

Abstract read
In one paragraph

Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Danlei LiuShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Shiwei YuShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Xiangting TianShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Zhiyi WangShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Ye LuShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Yue DaiShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Chunli HuShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Xinyi MaCenter for Global Health, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, P. R. China.
Mao MaoShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Liming XueShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Zaijiong YiShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Guannan ZhangShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Shenwei LiShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Qiang WangShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China.
Zilong ZhangShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China. heilong82@163.com.
Zhengan TianShanghai International Travel Healthcare Center, Shanghai Customs District P. R. China, Shanghai, 200136, China. tianzhenganciq@163.com.

Funding

General Administration of Customs Project 2024HK149National Key Research and Development Program of China 2022YFC2302800
6 · The paper itself

Abstract

backgroundNorovirus is a leading cause of acute gastroenteritis and spreads efficiently in closed, mobile cohorts such as organized travel groups. This case is notable for the real-time detection and genomic confirmation of a cross-border outbreak at a port of entry, including near-identical Norovirus GΙΙ.17[P17] genomes and documented asymptomatic carriage, illustrating the practical value of integrated metagenomic surveillance in border health operations. CASE PRESENTATION: On July 21, 2024, 26 travelers arrived at Shanghai Port after a 12-day group tour in Europe. Clinical interviews identified 15 individuals (57.7%) with diarrhea, nausea, dizziness, and abdominal pain; no hospitalizations occurred. On-site anal swab testing was negative for SARS-CoV-2, influenza A and B, Vibrio cholerae, and Escherichia coli. RT-qPCR detected Norovirus GII in 10 samples (38.5%), including two asymptomatic individuals. Metagenomic sequencing generated near-complete genomes for all RT-qPCR-positive samples, which were 99.9-100% identical and classified as Norovirus GΙΙ.17[P17], confirming a cross-border outbreak within the travel cohort. Prompt public health response measures were initiated by Shanghai Customs and CDC authorities.

conclusionsThis case demonstrates the feasibility and impact of rapid, genomically informed surveillance at the border for detecting and characterizing travel-associated enteric virus outbreaks. The findings underscore the need for robust port-of-entry monitoring, rapid diagnostics, and integrated genomic analysis to mitigate transmission in group travel settings.

Indexed as

Caliciviridae InfectionsDisease OutbreaksGastroenteritisNorovirusAdultChinaFemaleHumansMaleMiddle AgedPhylogenyTravelAcute gastroenteritisBorder surveillanceCross-border outbreakMetagenomic sequencingNorovirus

Identifiers

PMID41781897
PMCPMC13067527

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.