Evidence map›Paper›PMID 41781804›Full record

ArticleMolecular imaging and biology2026

Design of a Bifunctional pHLIP-RGD Scaffold for Site-Specific [

Mingming Yu, Yuehua Chen, Bangxu Yu, Xia Li, Yuan Su, Zhenguang Wang

Abstract read
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In one paragraph

Article in Molecular imaging and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mingming YuDepartment of Nuclear Medicine, the Affiliated Hospital of Qingdao University, Qingdao, 266100, China. mingmingyu@bjmu.edu.cn.ORCID 0000-0002-1156-005X
Yuehua ChenDepartment of Nuclear Medicine, the Affiliated Hospital of Qingdao University, Qingdao, 266100, China.
Bangxu YuDepartment of Nuclear Medicine, the Affiliated Hospital of Qingdao University, Qingdao, 266100, China.
Xia LiDepartment of Nuclear Medicine, the Affiliated Hospital of Qingdao University, Qingdao, 266100, China.
Yuan SuDepartment of Nuclear Medicine, the Affiliated Hospital of Qingdao University, Qingdao, 266100, China.
Zhenguang WangDepartment of Nuclear Medicine, the Affiliated Hospital of Qingdao University, Qingdao, 266100, China. wangzhenguang@qdu.edu.cn.

Funding

the Natural Science Foundation of Shandong Province ZR2021MH038
6 · The paper itself

Abstract

purposeTo develop a novel molecular scaffold designed for dual targeting via site-specific [ PROCEDURES: The pHLIP-RGD scaffold was synthesized by conjugating pHLIP variant 7 (var7) with cyclo(RGDfK) peptide. Pharmacokinetic assessment of [

results[

conclusionsThe heterodimeric radiotracer [

Indexed as

OligopeptidesProof of Concept StudyTechnetiumAnimalsCell Line, TumorFemaleHumansMembrane ProteinsMiceMice, NudeRadiochemistryRadiopharmaceuticalsTissue DistributionTomography, Emission-Computed, Single-Photonarginyl-glycyl-aspartic acidMembrane ProteinsOligopeptidespHLIP proteinRadiopharmaceuticalsTechnetiumHeterodimerIntegrin αvβ3PH (low) insertion peptidesTechnetium-99mTriple-negative breast cancerTumor microenvironment

Identifiers

PMID41781804

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.