Evidence map›Paper›PMID 41781796›Full record

ArticleBrain imaging and behavior2026

The shared and disorder-specific resting-state functional connectivity networks associated with emotion regulation between attention deficit/hyperactivity disorder and bipolar disorder.

Qian Zhuang, Chuxian Xu, Nuo Xu, Fanyi Feng, Matthew Lock, Shuaiyu Chen, Yufeng Zang

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Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Qian ZhuangCenter for Cognition and Brain Disorders, Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China. qianzhuang.uestc@outlook.com.
Chuxian XuCenter for Cognition and Brain Disorders, Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Nuo XuCenter for Cognition and Brain Disorders, Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Fanyi FengCenter for Cognition and Brain Disorders, Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Matthew LockCenter for Cognition and Brain Disorders, Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Shuaiyu ChenCenter for Cognition and Brain Disorders, Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China. daozhezifei@163.com.
Yufeng ZangCenter for Cognition and Brain Disorders, Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.

Funding

Medical and Health Technology Project of Zhejiang Provincial Health Commission 2021ky247Medical and Health Technology Project of Zhejiang Provincial Health Commission 2023RC236National Natural Science Foundation of China 32100888National Natural Science Foundation of China 32200904Natural Science Foundation of Zhejiang Province LQ21C090007
6 · The paper itself

Abstract

Emotion regulation deficits have been frequently observed in adults with attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD). Numerous studies have investigated the functional network properties in ADHD and BD, however, common and distinct alterations in emotion regulation associated resting state functional connectivity (rsFC) remain understudied. The current study was performed to determine shared and disorder-specific rsFC features with emotion regulation networks (ERNs) proposed by Morawetz et al. (Neuroscience And Biobehavioral Reviews, 116, 382–395, 2020) and their association with clinical symptoms. The whole-brain seed-to-voxel functional connectivity analyses were conducted using ERN regions as seeds on neuroimaging data from the OpenfMRI project (40 ADHD, 49 BD and 49 adults from healthy control group (HC). Our findings revealed significant shared and disorder-specific rsFC circuits mainly involving emotion perception and interoceptive processing but not executive control during emotion regulation. Compared to the HC and BD groups, the ADHD group showed significant enhanced functional connectivity between inferior occipital gyrus (IOG) and lingual/fusiform gyrus as well as between superior parietal lobule (SPL) and insula. In contrast, both ADHD and BD groups exhibited decreased connectivity between the precuneus and fusiform gyrus relative to the HC. Notably, IOG–lingual/fusiform gyrus connectivity was significantly associated with fidget symptoms in the ADHD group and with YMRS scores in the BD group. Together these findings advance the understanding of shared and disorder-specific rsFC underpinnings of emotion dysregulation in adults with ADHD and BD and may inform neuroimaging-based diagnostic approaches.

Indexed as

Attention Deficit Disorder with HyperactivityBipolar DisorderBrainEmotional RegulationAdultBrain MappingCerebral CortexFemaleHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysYoung AdultADHDBipolar disorderemotion regulationinsularesting state functional connectivity

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.