ArticleJournal of medical systems2026
Toward Effective Technology Support in DCTs: Insights from the Trials@Home Proof-of-Concept Trial RADIAL.
Article in Journal of medical systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05780151 (Pan-European Proof-of-concept Study Comparing Decentralised Clinical Trial), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pan-European Proof-of-concept Study Comparing Decentralised Clinical Trial (DCT) and Hybrid Approaches to Conventional Clinical Trial Approaches in Patients With Type 2 Diabetes Mellitus Treated With Toujeo®
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0 citing papers in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decentralized clinical trials (DCTs) increasingly rely on digital tools such as wearable devices, mobile applications, and online platforms to enable remote data collection and participant engagement. While these technologies offer opportunities for greater convenience and continuous data capture, they also introduce operational complexity and require comprehensive technical support for participants, clinical site staff, and study teams. This paper reports on the design, implementation, use, and evaluation of a dedicated support framework in the European proof-of-concept trial RADIAL, part of the Trials@Home project, aimed at identifying effective components and operational practices for supporting DCTs. The framework included an open-source ticketing system for structured issue management, a restricted-access knowledge base (KB) with training materials and troubleshooting guides, and governance processes for escalation and quality monitoring. Key performance indicators were derived from system databases to track ticket volume, resolution times, and KB usage. Over the trial’s 17-month reporting period, 169 tickets were submitted across 90% of active clinical trial sites, with device-related problems accounting for 46% of requests and study app queries for 17%. Half of all tickets were resolved within three days, and most required two to six replies. The KB logged 696 searches and 4,350 article views, with highest engagement around training materials and device-related instructions. Findings indicate that a successful support framework for DCTs requires a combination of ticketing, accessible documentation, live support options, and continuous governance. Lessons from RADIAL underscore the importance of multilingual support, proactive training, and flexible workflows to effectively mitigate operational complexity and ensure reliable trial conduct. This trial was registered with identifier NCT05780151 in clinicaltrials.gov and under 2022-500,449-26-00 in the Clinical Trials Information System (CTIS) clinical trial database.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.