ArticleAnalytical and bioanalytical chemistry2026
A streamlined in-syringe fast drug extraction and semi-automated dispersive cleanup technique for quick biomonitoring of direct oral anti-coagulant drugs in patients' plasma samples using UHPLC-MS/MS analysis.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In this work, the manual multistep QuEChERS (quick, easy, cheap, effective, rugged, and safe) approach has been streamlined into an in-syringe micro-QuEChERS method, referred to as an in-syringe-assisted fast drug extraction (IS-FaDEx) coupled with semi-automated (SA) dispersive solid-phase cleanup (dSPC), for fast quantification of direct oral anticoagulant drugs (DOACs) in human plasma samples using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) detection. In the IS-FaDEx-SA-dSPC method, 100 µL of plasma was taken into a 3-mL plastic syringe for salt-induced liquid-liquid extraction, after which the extractant was transferred to another 3-mL plastic syringe for the dSPC procedure using sorbents with salt (including C18, sorbent with primary-secondary amine functionalities, and anhydrous MgSO
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