In one paragraphArticle in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
- Erratum issued
- Erratum issued
5 · Who and what moneyAuthors and funding
11 authors.
Yuelin LiuNew Cornerstone Science Laboratory, Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0009-0007-3508-1188 Li FengShenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Changshi WangShenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0001-5206-9737 Wei YanNew Cornerstone Science Laboratory, Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0001-8086-9539 Qianyan LinghuNew Cornerstone Science Laboratory, Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Huijuan TanNew Cornerstone Science Laboratory, Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Yajie PanNew Cornerstone Science Laboratory, Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Siqi YanNew Cornerstone Science Laboratory, Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0009-0009-4562-3256 Jixian ZhaiShenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0002-0217-0666 Jiamu DuShenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0002-1337-0786 Hongwei GuoNew Cornerstone Science Laboratory, Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China. guohw@sustech.edu.cn.ORCID http://orcid.org/0000-0003-4819-5874 Funding
National Natural Science Foundation of China (National Science Foundation of China) 32261160572National Natural Science Foundation of China (National Science Foundation of China) 32325008National Natural Science Foundation of China (National Science Foundation of China) 32400449Shenzhen Science and Technology Innovation Commission JCYJ20190809163019421Shenzhen Science and Technology Innovation Commission JCYJ20250604144203004Shenzhen Science and Technology Innovation Commission KQTD20190929173906742Shenzhen Science and Technology Innovation Commission RCJC20221008092720004Shenzhen Science and Technology Innovation Commission ZDSYS20230626091659010
6 · The paper itselfAbstract
Small RNAs regulate eukaryotic development and immunity. In plants, multiple DICER-LIKE (DCL) proteins produce distinct small RNAs that play diverse functions. These DCL proteins act in a hierarchical manner, with DCL4 outcompeting DCL2 being particularly important for optimal gene expression and plant growth. However, the mechanism of this hierarchical action remains unclear. Here we reveal that the second double-stranded-RNA-binding domain (dsRBD2) of DCL4 interacts with DSRNA BINDING PROTEIN 4 (DRB4), a cofactor essential for DCL4's function. DRB4 dictates the relative biogenesis of 21- and 22-nucleotide small interfering RNAs derived from TAS loci and coding transcripts. All DCL2 proteins in seed plants lack dsRBD2; however, fusing dsRBD2 to DCL2 enhances its activity, leading to massive production of coding-transcript-derived small interfering RNAs, as well as growth defects and activated stress responses. These findings demonstrate the central role of the dsRBD2-DRB4 module, which enables DCL4 to outcompete DCL2, thereby preventing detrimental gene silencing.
Indexed as
ArabidopsisArabidopsis ProteinsCell Cycle ProteinsRibonuclease IIIRNA-Binding ProteinsGene Expression Regulation, PlantRNA, Small InterferingArabidopsis ProteinsCell Cycle ProteinsDCL2 protein, ArabidopsisDCL4 protein, ArabidopsisDRB4 protein, ArabidopsisRibonuclease IIIRNA-Binding ProteinsRNA, Small Interfering
What OpenQuestion holds
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