Evidence map›Paper›PMID 41781722›Full record

ArticleMolecular psychiatry2026

The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression.

Waki Nakajima, Mai Hatano, Yohei Ohtani, Hideaki Tani, Taisuke Yatomi, Shohei Tsuchimoto, Yu Fujimoto, Tsuyoshi Eiro, Sadamitsu Ichijo, Kotaro Nakano and 21 more

Abstract read
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Waki Nakajima *Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Mai Hatano *Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Yohei Ohtani *Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Hideaki TaniDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Taisuke YatomiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Shohei TsuchimotoDivision of Neural Dynamics, Department of System Neuroscience, National Institute for Physiological Sciences, Okazaki, Aichi, 444-8585, Japan.
Yu FujimotoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.ORCID http://orcid.org/0009-0004-0664-9529
Tsuyoshi EiroDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Sadamitsu IchijoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Kotaro NakanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Tetsu ArisawaRadioisotope Research Center, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.ORCID http://orcid.org/0000-0001-7694-8728
Yuuki TakadaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Kimito KimuraDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Hiroki AbeDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Akane SanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Kie Nomoto-TakahashiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Kengo YonezawaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Sota TomiyamaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Nobuhiro NagaiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Keisuke KusudoDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Shiori HondaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Sotaro MoriyamaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Shinichiro NakajimaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.ORCID http://orcid.org/0000-0002-2601-2195
Takashige YamadaDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, 160-8582, Japan.ORCID http://orcid.org/0000-0002-1152-9853
Yu IwabuchiDepartment of Radiology, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Masahiro JinzakiDepartment of Radiology, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Kimio YoshimuraDepartment of Health Policy and Management, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Shariful A SyedDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Sakiko TsugawaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.ORCID http://orcid.org/0000-0001-9974-316X
Hiroyuki UchidaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan. hiroyuki_uchida@keio.jp.ORCID http://orcid.org/0000-0002-0628-7036
Takuya TakahashiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan. takahast@yokohama-cu.ac.jp.ORCID http://orcid.org/0000-0001-6523-0622

Funding

Japan Agency for Medical Research and Development (AMED) JP14dm0207023Japan Agency for Medical Research and Development (AMED) JP16dm0107124Japan Agency for Medical Research and Development (AMED) JP19dm0207072Japan Agency for Medical Research and Development (AMED) JP24wm0625304Japan Agency for Medical Research and Development (AMED) JP25gm7010019MEXT | Japan Society for the Promotion of Science (JSPS) 19H03587MEXT | Japan Society for the Promotion of Science (JSPS) 20H00549MEXT | Japan Society for the Promotion of Science (JSPS) 20H05922MEXT | Japan Society for the Promotion of Science (JSPS) 20K20603MEXT | Japan Society for the Promotion of Science (JSPS) 21K07508MEXT | Japan Society for the Promotion of Science (JSPS) 22H03001MEXT | Japan Society for the Promotion of Science (JSPS) 22K15793MEXT | Japan Society for the Promotion of Science (JSPS) 23K10432
6 · The paper itself

Abstract

Approximately 30% of patients with depression suffer from treatment-resistant depression (TRD). Ketamine has shown antidepressant efficacy for TRD. While glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) has been demonstrated to play crucial roles in the process of pharmacological action of ketamine in experimental animals, it remains elusive how ketamine exhibits its efficacy through changes in AMPAR dynamics in patients with TRD. In this study, using a positron emission tomography (PET) tracer, [

Indexed as

Depressive Disorder, Treatment-ResistantKetamineReceptors, AMPAAdultAntidepressive AgentsBrainDepressionFemaleHumansMaleMiddle AgedPositron-Emission TomographyAntidepressive AgentsKetamineReceptors, AMPA

Identifiers

PMID41781722
PMCPMC13269144

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.