ArticleEuropean journal of nuclear medicine and molecular imaging2026
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Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeGallium-68([68Ga])-labeled Ga-NOTA-T4 PET/CT is a promising noninvasive imaging tool for visualizing trophoblast cell-surface antigen 2 (TROP2) expression, which could aid clinical decisions regarding TROP2-targeted therapies. This study aims to evaluate the diagnostic performance of [68Ga]Ga-NOTA-T4 PET/CT, a novel TROP2-targeting tracer, for detecting TROP2 expression in HER2-negative breast cancer.
methodsFrom September 2023 to March 2025, we retrospectively reviewed patients with HER2-negative breast cancer at Huashan Hospital, Fudan University. All participants underwent [68Ga]Ga-NOTA-T4 PET/CT, with or without [18F]FDG PET/CT.
resultsA total of 42 patients were enrolled in the study, among whom 27 underwent both [68Ga]Ga-NOTA-T4 and [18F]FDG PET/CT imaging. [68Ga]Ga-NOTA-T4 PET/CT demonstrated comparable capability to [18F]FDG in identifying both patients and metastatic lesions. Among patients with Luminal B HER2-negative breast cancer, those who had received endocrine therapy or chemotherapy demonstrated significantly higher [⁶⁸Ga]Ga-NOTA-T4 uptake compared to untreated patients (SUVmax: 5.20 ± 5.07 vs. 3.36 ± 3.52; p = 0.008). A similar trend was observed in Luminal A patients, with higher SUVmax values in the treated group; however, the difference did not reach statistical significance (SUVmax: 8.35 ± 6.41 vs. 5.60 ± 4.55; p = 0.241). In TNBC patients, treatment was associated with significantly lower [⁶⁸Ga]Ga-NOTA-T4 uptake compared to those who were untreated (SUVmax: 3.02 ± 2.35 vs. 7.63 ± 5.64; p = 0.008).
conclusions[68Ga]Ga-NOTA-T4 PET/CT is a promising tool for visualizing TROP2 expression in breast cancer, with potential applications for patient stratification and precision therapy. In Luminal B breast cancer, SUVmax increased with initial TROP2-targeted ADC therapy but decreased after multiple endocrine therapy or chemotherapy treatments. In TNBC, SUVmax decreased upon initial therapy.
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