Evidence map›Paper›PMID 41781702›Full record

ArticleActa pharmacologica Sinica2026

Targeted tumor starvation strategy augments radiosensitivity and enhances radioactive iodine-mediated tumor immunotherapy.

Ying Zhang, Zhi-Peng Liu, Zi-Yang Zhang, Jin Tian, Ren-Li Luo, Ming-Mei Dong, Chuan-Zheng Zhou, Jung-Joon Min, Zhen Cheng, Yeongjin Hong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ying ZhangState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. zhangying@simm.ac.cn.
Zhi-Peng LiuDepartment of Neurosurgery, Ningbo No. 2 Hospital, Ningbo, 315000, China.
Zi-Yang ZhangState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Jin TianState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Ren-Li LuoState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Ming-Mei DongThe Second Affiliated Hospital of Harbin Medical University, Harbin, 150000, China.
Chuan-Zheng ZhouSchool of Life Science, Huaibei Normal University, Huaibei, 235000, China.
Jung-Joon MinInstitute for Molecular Imaging and Theranostics, Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Jeollanam-do, 58128, Republic of Korea. jjmin@jnu.ac.kr.
Zhen ChengState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. zcheng@simm.ac.cn.
Yeongjin HongInstitute for Molecular Imaging and Theranostics, Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Jeollanam-do, 58128, Republic of Korea. yjhong@jnu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiopharmaceutical therapy (RPT) represents a critical approach in oncology, nevertheless its efficacy may be limited by tumor resistance mechanisms associated with metabolic reprogramming. Enhancing tumor radiosensitivity remains a major challenge. Engineered bi-functional starvation probes (CRT3LP and CRT4LP) that simultaneously target ecto-CRT and exert L-ASNase activity are explored for disrupting tumor amino acid metabolism. Herein, we systematically evaluate the ability of targeted starvation probes to enhance antitumor efficacy in radioactive iodine (RAI) therapy. In vitro, the probes upregulated p53 expression while downregulating Rev1 and SOD

Indexed as

ImmunotherapyIodine RadioisotopesNeoplasmsRadiation ToleranceRadiopharmaceuticalsAnimalsCell Line, TumorHumansMiceIodine RadioisotopesRadiopharmaceuticalsimmune checkpoint inhibitorsradiosensitivityROSRPTstarvation probes

Identifiers

PMID41781702
PMCPMC13279799

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.