Evidence map›Paper›PMID 41781695›Full record

ArticleBrain imaging and behavior2026

Activation in the right orbitofrontal cortex during pain processing as a transdiagnostic neural representation in suicide attempters.

Haobing Wei, Huanhuan Li, Ziyu Hao, Yuying Chen, Jiahe Chen, Youwei Fu

Abstract read
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In one paragraph

Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Haobing WeiDepartment of Psychology, Renmin University of China, Floor 10, Suite D, Huixian Building, 59 Zhongguancun Street, Haidian District, Beijing, 100872, China.
Huanhuan LiDepartment of Psychology, Renmin University of China, Floor 10, Suite D, Huixian Building, 59 Zhongguancun Street, Haidian District, Beijing, 100872, China. psylihh@ruc.edu.cn.
Ziyu HaoDepartment of Psychology, Renmin University of China, Floor 10, Suite D, Huixian Building, 59 Zhongguancun Street, Haidian District, Beijing, 100872, China.
Yuying ChenDepartment of Psychology, Renmin University of China, Floor 10, Suite D, Huixian Building, 59 Zhongguancun Street, Haidian District, Beijing, 100872, China.
Jiahe ChenDepartment of Psychology, Renmin University of China, Floor 10, Suite D, Huixian Building, 59 Zhongguancun Street, Haidian District, Beijing, 100872, China.
Youwei FuDepartment of Psychology, Renmin University of China, Floor 10, Suite D, Huixian Building, 59 Zhongguancun Street, Haidian District, Beijing, 100872, China.

Funding

Natural Science Foundation of Beijing Municipality 5242012
6 · The paper itself

Abstract

Psychological pain serves as a robust predictor of suicide attempts (SAs) in patients with major depressive disorder (MDD). However, the neural characteristics of pain processing, independent of specific psychiatric diagnoses, and their relationships with SAs remain unclear. This study aimed to identify transdiagnostic and transparadigmatic neural correlates of pain processing in suicide attempters with mood disorders. Participants were categorized into groups and subgroups based on their suicide attempt histories, diagnostic category, and the task paradigms they completed. Representational similarity analyses were utilized both in regions of interest and through whole-brain searchlight analysis to explore psychological pain-induced neural patterns linked to SAs. Our findings demonstrate that, at the behavioral levels, pain avoidance is a significant transdiagnostic predictor of SAs across mood disorders. The MDD-SA group exhibited a transparadigmatic neural consistency in the left middle orbitofrontal cortex (OFC) and bilateral thalamus during punishment processing. Furthermore, a transdiagnostic SA-related activation pattern was identified in the right OFC, characterized by distinct spatial configurations rather than diffuse activity.

Indexed as

PainPain PerceptionPrefrontal CortexSuicide, AttemptedAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleMood DisordersYoung AdultFunctional magnetic resonance imagingMood disorderPsychological painRepresentational similarity analysisSuicide attempt

Identifiers

PMID41781695

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.