Evidence map›Paper›PMID 41781681›Full record

SynthesisScientific reports2026

Physical and respiratory training in patients with myasthenia gravis: a systematic review with meta-analysis.

Guillermo Gutierrez-Del-Val, Victor Serrano-Fernandez, Victoria Mazoteras-Pardo, Rosa Maria Molina-Madueño, Carmen Bouzas-Mosquera, Juan Manuel Carmona-Torres, Jose Alberto Laredo-Aguilera

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guillermo Gutierrez-Del-ValHospital Universitario de Toledo, Avda. Rio Guadiana s/n, 45007, Toledo, Spain.
Victor Serrano-FernandezFacultad de Fisioterapia y Enfermería, Universidad de Castilla-La Mancha, Avda. Carlos III s/n, 45071, Toledo, Spain. victor.serrano@uclm.es.
Victoria Mazoteras-PardoFacultad de Enfermería de Ciudad Real, Universidad de Castilla-La Mancha, C. Altagracia 50, 13001, Ciudad Real, Spain.
Rosa Maria Molina-MadueñoHospital Universitario de Toledo, Avda. Rio Guadiana s/n, 45007, Toledo, Spain.
Carmen Bouzas-MosqueraHospital Universitario de Toledo, Avda. Rio Guadiana s/n, 45007, Toledo, Spain.
Juan Manuel Carmona-TorresFacultad de Fisioterapia y Enfermería, Universidad de Castilla-La Mancha, Avda. Carlos III s/n, 45071, Toledo, Spain.
Jose Alberto Laredo-AguileraFacultad de Fisioterapia y Enfermería, Universidad de Castilla-La Mancha, Avda. Carlos III s/n, 45071, Toledo, Spain.

Funding

FEDER-UCLM UCLM 2022
6 · The paper itself

Abstract

Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction, leading to impaired muscle function. This systematic review aimed to evaluate the current scientific evidence on the effects of training programs on symptom severity, performance in activities of daily living, quality of life, physical fitness, and respiratory function in individuals with myasthenia gravis. A systematic review and meta-analysis were conducted following the PRISMA guidelines. Searches were performed in PubMed, Scopus, Web of Science, and CINAHL Complete databases. Outcomes of interest included symptom severity scores, quality of life, activities of daily living performance, physical fitness, and respiratory parameters. A total of 1564 records were identified. After removing duplicates and screening titles, abstracts, and full texts, 20 studies were included in the qualitative synthesis, with 10 of them contributing to quantitative meta-analyses. Training interventions were associated with reductions in symptoms, as well as improvements in quality of life and performance in activities of daily living. Additionally, enhancements were observed in muscle strength, distance covered, and respiratory parameters. Physical activity and respiratory training may offer multiple benefits for patients with myasthenia gravis. Nevertheless, individualized exercise programs are essential to ensure safety and optimize adherence among this population.

Indexed as

Breathing ExercisesExerciseExercise TherapyMyasthenia GravisActivities of Daily LivingHumansMuscle StrengthPhysical FitnessQuality of LifeMeta-analysisMyasthenia gravisPhysical activityRespiratory trainingSystematic review

Identifiers

PMID41781681
PMCPMC13068943

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.