ArticleNature2026
Cell-free chromatin state tracing reveals disease origin and therapy responses.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Targeting progressive multiple sclerosis: Toward mechanism-informed precision medicine.Journal of internal medicine · 2026Review
- Using Disease-Agnostic Genomic Liquid Biopsy in Complex Diagnoses: Real-Life Example of cfChIP-Seq in a Fever of Unknown Origin.JCO precision oncology · 2026Article
- Advancements and Clinical Applications Prospects of Epigenetic Biomarkers in Liquid Biopsy for Oral Squamous Cell Carcinoma.Current issues in molecular biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors.
Xubin Chen *Key laboratory of Carcinogenesis and Translational Research of Ministry of Education of China, Peking University Cancer Hospital and Institute, Peking University, Beijing, China.ORCID http://orcid.org/0009-0007-2619-2310
Xiaoxuan Meng *Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Weilong Zhang *Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China.ORCID http://orcid.org/0000-0001-7792-3389
Xiawei Zhang *Medical School of Chinese PLA, Beijing, China.
Yaping ZhangHongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ping YangDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China.
Yan LiuDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China.ORCID http://orcid.org/0000-0002-1307-9403
Fang BaoDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China.
Sen LiDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China.
Jing WangDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China.
Changjian YanDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China.ORCID http://orcid.org/0000-0002-1167-070X
Chunyuan LiDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China.
Lingke ZhangDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China.
Xiaoyu HaoDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China.
Jia LiuDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China.
Jing SunDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0003-2110-5189
Zhengting WangDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-5533-5711
Yu TianPeking University First Hospital, Beijing, China.
Liqing ZhuDepartment of Clinical Laboratory, Peking University Cancer Hospital and Institute, Peking University, Beijing, China.
Yan HouDepartment of Biostatistics, School of Public Health, Peking University, Beijing, China.
Zongchao LiuState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China.
Wenqing LiState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China.
Lan MiKey laboratory of Carcinogenesis and Translational Research (Ministry of Education), lymphoma department, Peking University Cancer Hospital and Institute, Beijing, China.
Xinyu QiKey laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital and Institute, Beijing, China.
Yanzhu YueDepartment of Cell Fate and Diseases, Jilin Provincial Key Laboratory of Women's Reproductive Health, Jilin Provincial Clinical Research Center for Birth Defect and Rare Disease, the First Hospital of Jilin University, Changchun, China.
Peng DuPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Guoqiang ChenInstitute of Aging and Tissue Regeneration, Stress and Cancer Research Unit of Chinese Academy of Medical Sciences, State Key Laboratory of Systems Medicine for Cancer, Ren-Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0003-4936-2363
Junke ZhengInstitute for Translational Medicine on Cell Fate and Disease, Shanghai Ninth People's Hospital, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhengjunke@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-7023-2400
Liping DouState Key Laboratory of Experimental Hematology, Senior Department of Hematology, the Fifth Medical Center of PLA General Hospital, Beijing, China. lipingruirui@163.com.ORCID http://orcid.org/0000-0001-7352-9560
Hongmei JingDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China. hongmeijing@bjmu.edu.cn.ORCID http://orcid.org/0000-0003-4958-2489
Aibin HeKey laboratory of Carcinogenesis and Translational Research of Ministry of Education of China, Peking University Cancer Hospital and Institute, Peking University, Beijing, China. ahe@pku.edu.cn.ORCID http://orcid.org/0000-0002-3489-2305
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-free DNA in blood originates from fragmented chromatin released by dying cells from both healthy and diseased tissues
Indexed as
Cell-Free Nucleic AcidsChromatinColorectal NeoplasmsEpigenesis, GeneticFemaleHistone CodeHistonesHumansInflammatory Bowel DiseasesLymphoma, Large B-Cell, DiffuseLymphoma, Mantle-CellMachine LearningMaleCell-Free Nucleic AcidsChromatinHistones
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.