Evidence map›Paper›PMID 41781609›Full record

ArticleNature2026

Structural basis of RNA-guided transcription by a dCas12f-σ

Renjian Xiao, Florian T Hoffmann, Dan Xie, Tanner Wiegand, Adriana I Palmieri, Samuel H Sternberg, Leifu Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Renjian Xiao *Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-5914-0812
Florian T Hoffmann *Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0003-0301-4259
Dan XieDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Tanner WiegandDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-0528-268X
Adriana I PalmieriDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Samuel H SternbergDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. shsternberg@gmail.com.ORCID http://orcid.org/0000-0001-8240-9114
Leifu ChangDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA. lchang18@purdue.edu.ORCID http://orcid.org/0000-0002-6107-5271

Funding

Molecular basis for CRISPR RNA-guided nucleic acid cleavage and DNA transpositionR01GM138675 · NIGMS · PURDUE UNIVERSITY · PI CHANG, LEIFU · 2020 to 2024
$1.8M
Molecular basis for CRISPR-associated transposons and RNA-guided transcriptional regulationR35GM158248 · NIGMS · PURDUE UNIVERSITY · PI Leifu Chang · 2025 to 2026
$923k
Acquisition of Trapped Ion Mobility Spectrometry Time of Flight Mass SpectrometerS10OD032364 · OD · PURDUE UNIVERSITY · PI ARYAL, UMA K. · 2023 to 2023
$600k
NIGMS NIH HHS R01 GM138675NIGMS NIH HHS R35 GM158248NIH HHS S10 OD032364
6 · The paper itself

Abstract

In both natural and engineered biological systems, RNA-guided proteins have emerged as critical transcriptional regulators by modulating RNA polymerase (RNAP) and its associated factors

Indexed as

Bacterial ProteinsCRISPR-Associated ProteinsDNA-Directed RNA PolymerasesRNA, Guide, CRISPR-Cas SystemsSigma FactorTranscription Initiation, GeneticCRISPR-Cas SystemsCryoelectron MicroscopyDNAGene Expression Regulation, BacterialHoloenzymesModels, MolecularTranscription, GeneticBacterial ProteinsCRISPR-Associated ProteinsDNADNA-Directed RNA PolymerasesHoloenzymesRNA, Guide, CRISPR-Cas SystemsSigma Factor

Identifiers

PMID41781609
PMCPMC13408147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.