ArticleScientific reports2026
NvashA function reveals temporal differences in neural subtype generation in cnidarians.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Revisiting nerve nets: functional organization and evolutionary implications.The EMBO journal · 2026Review
- Lineage-specific elaboration of a conserved cnidogenic program drives cnidocyte diversification and illuminates cell type evolution.Research square · 2026Article
- International workshop report on "Animal resilience and organismal response to environmental change: insights from basal metazoans", Tutzing (Germany), 22-25 September 2025.Frontiers in zoology · 2026Article
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Abstract
Understanding how cnidarians pattern their nervous systems can provide insight into the ancestral mechanisms of neurogenesis that are shared with bilaterians, shedding light on the evolution of nervous systems. While previous studies revealed conserved mechanisms for neural induction, progenitor selection, and spatial patterning mechanisms between cnidarians and bilaterians, less is known about how distinct neuronal subtypes are specified over time in cnidarians. We utilized single-cell mRNA sequencing to profile NvashA-expressing cells across embryonic and planula-larva stages of Nematostella vectensis neurogenesis, and functional experiments to demonstrate that different neuronal fates are arising in a temporal pattern during embryonic and larval stages. These data demonstrate that there is a temporal component to neuronal patterning in Nematostella, which is consistent with mechanisms of neurogenesis observed in bilaterian model systems. These data further strengthen the conclusion that cnidarian nerve nets and complex bilaterian centralized nervous systems evolved from a common ancestor that utilized similar spatiotemporal patterning strategies to generate neuronal cell type diversity.
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