Evidence map›Paper›PMID 41781504›Full record

ReviewPlanta2026

Decoding the multifunctional role of γ-aminobutyric acid in plant adaptation to drought stress.

Hossam S El-Beltagi, Mohamed Abdel-Haleem, Tarek A Shalaby, Emad H Khedr

Abstract readReview
PubMed Publisher
In one paragraph

Review in Planta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hossam S El-BeltagiAgricultural Biotechnology Department, College of Agriculture and Food Sciences, King Faisal University, 31982, Al-Ahsa, Saudi Arabia. helbeltagi@kfu.edu.sa.
Mohamed Abdel-HaleemDepartment of Botany and Microbiology, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.
Tarek A ShalabyDepartment of Arid Land Agriculture, College of Agriculture and Food Sciences, King Faisal University, 31982, Al-Ahsa, Saudi Arabia.
Emad H KhedrDepartment of Pomology, Faculty of Agriculture, Cairo University, Giza, 12613, Egypt. emad.khedr@agr.cu.edu.eg.ORCID http://orcid.org/0009-0004-0501-9277

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MAIN

conclusionGABA acts as a central integrator of molecular, physiological, and metabolic responses, enhancing drought tolerance by improving water-use efficiency, osmotic balance, redox homeostasis, and stress signaling. Drought is one of the most severe abiotic stresses, limiting plant growth, yield, and global food security under climate change and resource scarcity. Gamma-aminobutyric acid (GABA), a non-proteinogenic amino acid, acts as a multifunctional regulator of plant drought tolerance by orchestrating physiological, biochemical, and molecular responses. GABA enhances osmotic adjustment, antioxidant defense, and stomatal regulation, promotes proline accumulation, and interacts with polyamines and hormonal pathways such as ABA, collectively improving water-use efficiency and mitigating oxidative stress. Its metabolism and signaling integrate diverse cellular processes, enabling efficient stress perception, adaptation, and maintenance of cellular homeostasis. GABA also coordinates metabolic crosstalk, supporting stress-responsive networks that enhance resilience under water-limited conditions. By modulating these interconnected pathways, GABA contributes to improved plant survival, growth, and productivity during drought. Exploiting GABA-mediated mechanisms offers promising strategies for enhancing crop drought tolerance, sustaining agricultural productivity, and guiding future research toward practical applications. This review synthesizes current knowledge on GABA's multifunctional role in drought adaptation, encompassing metabolic regulation, physiological responses, stomatal control, antioxidant systems, and interactions with polyamines, providing an integrated perspective on its potential to improve plant resilience under increasingly frequent and severe water-deficit conditions.

Indexed as

gamma-Aminobutyric AcidAdaptation, PhysiologicalDrought ResistanceDroughtsPlant StomataProlineSignal TransductionStress, Physiologicalgamma-Aminobutyric AcidProlineAbiotic stressOsmotic regulationPolyaminesProlineStomatal regulation

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.