Evidence map›Paper›PMID 41781492›Full record

ArticleExperimental & molecular medicine2026

Deficiency of exocyst complex component Exoc5 exacerbates the progression of kidney fibrosis.

Hui Jae Lim, Yong Kwon Han, Mi Ra Noh, You Ri Park, Se Young Jang, Joshua H Lipschutz, Kwon Moo Park

Abstract read
In one paragraph

Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hui Jae LimDepartment of Biomedical Science and BK21 Plus, The Graduate School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Yong Kwon HanDepartment of Anatomy, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Mi Ra NohDepartment of Biomedical Science and BK21 Plus, The Graduate School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
You Ri ParkDepartment of Biomedical Science and BK21 Plus, The Graduate School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Se Young JangDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
Joshua H LipschutzDepartments of Medicine, Medical University of South Carolina and Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA. Lipschut@musc.edu.ORCID http://orcid.org/0000-0002-7787-8503
Kwon Moo ParkDepartment of Biomedical Science and BK21 Plus, The Graduate School of Medicine, Kyungpook National University, Daegu, Republic of Korea. kmpark@knu.ac.kr.ORCID http://orcid.org/0000-0002-1617-5919

Funding

National Research Foundation of Korea (NRF) 2020R1A2C2006903National Research Foundation of Korea (NRF) 2025-21082988U.S. Department of Veterans Affairs (Department of Veterans Affairs) CX002391and BX000820
6 · The paper itself

Abstract

Fibrosis, an undesirable side effect of the repair process, is due to aberrant cell differentiation and is a typical cause of progressive diseases including chronic kidney disease (CKD). Exocyst complex component 5 (Exoc5), a central component of the highly-conserved eight-protein exocyst complex, is involved in cell differentiation and maturation; however, the role of Exoc5 in fibrosis remains to be defined. Here we investigate the role and underlying molecular mechanisms of Exoc5 on kidney development and fibrosis using kidney proximal tubule cell-specific Exoc5-knockout (PT-Exoc5

Indexed as

KidneyKidney DiseasesAnimalsDisease Models, AnimalDisease ProgressionFibrosisHumansMaleMiceMice, Knockout

Identifiers

PMID41781492
PMCPMC13049091

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.