Evidence map›Paper›PMID 41781486›Full record

ReviewNature reviews. Molecular cell biology2026

Neural crest gene regulatory networks as drivers of development, diversification and disease.

Jan Stundl, Ayyappa Raja Desingu Rajan, Marianne E Bronner

Abstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The lipid raft-linker gene Raftlin-2 is expressed in migrating neural crest cells.Differentiation; research in biological diversity · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jan StundlDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-3740-3378
Ayyappa Raja Desingu RajanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-0173-0465
Marianne E BronnerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. mbronner@caltech.edu.ORCID http://orcid.org/0000-0003-4274-1862

Funding

Progressive acquisition of novel neural crest derivatives along the neural axis during vertebrate evolutionR35NS111564 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Marianne Bronner · 2019 to 2026
$5.0M
Cell lineage and transcriptional analysis of the vertebrate neural plate borderR01DE027538 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Marianne Bronner · 2018 to 2026
$4.4M
Gene Regulatory Network Controlling Premigratory Cranial vs Trunk Neural CrestR01DE024157 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BRONNER, MARIANNE · 2014 to 2025
$4.0M
From Crest to Bone: Understanding neural crest skeletogenic capacity along the neural axisK99DE034068 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Jan Stundl · 2025 to 2026
$325k
Investigating the Regulatory Logic Underlying Meningeal Development and TumorigenesisK99DE034827 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Ayyappa Raja Desingu Rajan · 2025 to 2026
$325k
NIDCR NIH HHS K99 DE034068NIDCR NIH HHS K99 DE034827NIDCR NIH HHS R01 DE024157NIDCR NIH HHS R01 DE027538NINDS NIH HHS R35 NS111564
6 · The paper itself

Abstract

The neural crest is an important stem cell population characterized by its multipotency, migratory behaviour and broad ability to differentiate into numerous derivatives throughout the vertebrate body, as diverse as cell types contributing to the cardiovascular system, craniofacial skeleton, peripheral nervous system and pigmentation of the skin. The developmental trajectory of the neural crest is governed by a complex gene regulatory network (GRN) that mediates induction and specification at the neural plate border, emergence of neural crest cells (NCCs) from the neural tube, their migration through the periphery and cell fate determination en route to different final destinations. In this Review, we discuss the significant progress in investigating the neural crest GRN, which has increased our understanding of how NCCs impact vertebrate development and evolution, their role in adult tissue regeneration and their contribution to diseases derived from abnormalities in NCCs.

Indexed as

Gene Regulatory NetworksNeural CrestAnimalsCell DifferentiationCell MovementGene Expression Regulation, DevelopmentalHumans

Identifiers

PMID41781486
PMCPMC13085950

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.