Evidence map›Paper›PMID 41781470›Full record

ArticleArchives of virology2026

Validation of important genes and bioinformatics investigation of the relationship between ferroptosis and CVA16 infection.

Jianing Wang, Yanna Gao, Lujia Guo, Yinghui Pan, Binlian Sun, Yongjuan Liu, Yingying Shi

Abstract read
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In one paragraph

Article in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jianing WangDepartment of Immunology, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China.
Yanna GaoDepartment of Immunology, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China.
Lujia GuoDepartment of Immunology, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China.
Yinghui PanDepartment of Immunology, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China.
Binlian SunDepartment of Immunology, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China.
Yongjuan LiuDepartment of Central Laboratory, the Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, 222002, China. lyjquanzhiyuan_09@163.com.
Yingying ShiDepartment of Immunology, School of Medicine, Jianghan University, Wuhan, Hubei, 430056, China. shiyingying@jhun.edu.cn.ORCID http://orcid.org/0000-0002-2246-8582

Funding

National Natural Sciences Foundation of China 82202494
6 · The paper itself

Abstract

Coxsackievirus A16 (CVA16) is a major pathogen linked to hand, foot, and mouth disease (HFMD), and effective therapies and vaccines are lacking. Ferroptosis, an iron-dependent form of cell death, may play a role in CVA16 infection and remains underexplored. We analyzed microarray datasets (GSE71673) from the Gene Expression Omnibus (GEO) and ferroptosis-related genes (FRGs) from FerrDb. A Venn diagram revealed 37 ferroptosis-related differentially expressed genes (FR-DEGs), and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted on these genes. Protein-protein interaction (PPI) analysis revealed seven hub genes, and five hub genes were validated in CVA16-infected U251 cells via quantitative reverse transcription polymerase chain reaction (qRT-PCR). We constructed various interaction networks via the Network Analyst platform, revealing complex relationships between FR-DEGs. This study enhances the understanding of the molecular mechanisms linking ferroptosis and CVA16 infection, offering insights and therapeutic targets for its prevention and treatment.

Indexed as

Enterovirus A, HumanFerroptosisHand, Foot and Mouth DiseaseComputational BiologyGene Expression ProfilingGene OntologyGene Regulatory NetworksHost-Pathogen InteractionsHumansProtein Interaction MapsBioinformaticsCoxsackievirus A16 (CVA16)FerroptosisFerroptosis-related differentially expressed genesNetwork analysis

Identifiers

PMID41781470

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.