Evidence map›Paper›PMID 41781451›Full record

ArticleScientific reports2026

Sex-dependent dysregulation of the gut-brain NPYergic system in a mouse model of autism spectrum disorder.

Beatriz Martins, João Martins, Miguel Castelo-Branco, Joana Gonçalves

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Beatriz MartinsCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
João MartinsCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
Miguel Castelo-BrancoCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
Joana GonçalvesCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal. jgoncalves@ff.uc.pt.

Funding

Fundação para a Ciência e a Tecnologia 2022.01066.PTDCFundação para a Ciência e a Tecnologia FCT/UIDP&B/04950/2025Fundação para a Ciência e a Tecnologia UI/BD/150837/2021
6 · The paper itself

Abstract

The microbiome-gut-brain axis has been increasingly recognized for its role in the pathophysiology of autism spectrum disorder (ASD), yet the underlying molecular mechanisms remain poorly understood. Neuropeptide Y (NPY), a key modulator of gut-brain communication, may play a pivotal role in this axis. This study investigated the sex-specific molecular profile of the NPY system in gut-brain communication via a genetic mouse model of ASD, the Nf1

Indexed as

Autism Spectrum DisorderBrainNeuropeptide YAnimalsDisease Models, AnimalFemaleGastrointestinal MicrobiomeMaleMiceReceptors, Neuropeptide YSex CharacteristicsSex FactorsNeuropeptide YReceptors, Neuropeptide YAutism spectrum disorderGut-brainNeuropeptide YSex dimorphism

Identifiers

PMID41781451
PMCPMC13068916

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.