Evidence map›Paper›PMID 41781335›Full record

ArticleGenome research2026

Confounding factors in assessing the enriched expression of somatic mutant alleles in bulk tumor samples.

Kohei Hagiwara, Andrew Thrasher, Nadezhda V Terekhanova, Jinghui Zhang

Abstract read
In one paragraph

Article in Genome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Kohei HagiwaraDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.ORCID 0000-0001-7787-2008
Andrew ThrasherDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Nadezhda V TerekhanovaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA jinghui.zhang@stjude.org.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
NCI NIH HHS 3P30CA021765-41S3NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

Allele-specific expression (ASE) of somatic mutations can be caused by

Indexed as

AllelesGene Expression Regulation, NeoplasticMutationNeoplasmsCutaneous Squamous Cell CarcinomaHumansINDEL MutationNonsense Mediated mRNA Decay

Identifiers

PMID41781335
PMCPMC13138019

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.