Evidence map›Paper›PMID 41781332›Full record

ArticleGenome research2026

Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease.

Kangli Wang, Weikun Xia, Yingli Gu, Songpeng Zu, Qian Yang, Maria Luisa Amaral, Yaozhi Wang, Allen Wang, Xiang-Dong Fu, William C Mobley and 1 more

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In one paragraph

Article in Genome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kangli WangDepartment of Cellular and Molecular Medicine, University of California San Diego, School of Medicine, La Jolla, California 92093, USA.
Weikun XiaDepartment of Cellular and Molecular Medicine, University of California San Diego, School of Medicine, La Jolla, California 92093, USA.
Yingli GuDepartment of Cellular and Molecular Medicine, University of California San Diego, School of Medicine, La Jolla, California 92093, USA.
Songpeng ZuDepartment of Cellular and Molecular Medicine, University of California San Diego, School of Medicine, La Jolla, California 92093, USA.
Qian YangCenter for Epigenomics, University of California San Diego, School of Medicine, La Jolla, California 92093, USA.
Maria Luisa AmaralDepartment of Cellular and Molecular Medicine, University of California San Diego, School of Medicine, La Jolla, California 92093, USA.
Yaozhi WangDepartment of Cellular and Molecular Medicine, University of California San Diego, School of Medicine, La Jolla, California 92093, USA.
Allen WangCenter for Epigenomics, University of California San Diego, School of Medicine, La Jolla, California 92093, USA.
Xiang-Dong FuWestlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China.
William C MobleyDepartment of Neuroscience, University of California San Diego, La Jolla, California 92093, USA.
Bing RenDepartment of Cellular and Molecular Medicine, University of California San Diego, School of Medicine, La Jolla, California 92093, USA; br2833@cumc.columbia.edu.

Funding

Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NIH HHS S10 OD026929
6 · The paper itself

Abstract

Parkinson's disease (PD) is a prevalent neurodegenerative disorder predominantly affecting individuals over 60. Its motor symptoms stem from the deterioration of dopaminergic neurons within the substantia nigra. Despite aging being a significant risk factor, the specific mechanisms linking aging and PD pathology remain unclear. Leveraging advancements in single-cell genomics, this study utilizes single-nucleus multiome sequencing to capture transcriptomic and epigenetic profiles from 40,125 cells across the lifespan of the mouse substantia nigra. Our analysis pinpoints age-associated changes at a cell type-specific level, revealing a subset of genes that increasingly express with age and are enriched in PD-related pathways, notably in oligodendrocytes at late aging stages. Integration with five public PD single-cell RNA-seq data sets highlights 85 genes consistently differentially expressed with aging and PD. Key genes such as

Indexed as

AgingParkinson DiseaseSubstantia NigraAnimalsGene Expression ProfilingMiceMicrogliaMultiomicsOligodendrogliaSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisTranscriptome

Identifiers

PMID41781332
PMCPMC13138337

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.