ArticleChirality2026
Resolution of a Chiral β-Aminoketone via Diastereomeric Salt Formation: From Experimental Evidence to Molecular-Level Insights Into Solution-Phase Clusters.
Article in Chirality, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
The classical diastereomeric salt resolution approach was employed to separate (±)-1,3-diphenyl-3-(phenylamino)propan-1-one using both enantiomers of 10-camphorsulfonic acid (CSA) as resolving agents. Gentle stirring at room temperature resulted in the stereoselective precipitation of a single diastereomeric salt, yielding a solid phase highly enriched in one enantiomer of the target compound. Control experiments confirmed the crucial role of the chiral counterion in directing the selectivity of the process. Molecular Dynamics simulations and subsequent Principal Component Analysis revealed slight but significant differences in the pre-nucleation size distribution of ionic clusters and in the dynamics of their mutual interconversion, hence suggesting that these differences could play a role in the racemic resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.