ArticleAnnals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia2026
Preoperative Low Serum Basophil Levels Predict Poor Prognosis for the Patients with Esophageal Squamous Cell Carcinoma.
Article in Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeA decrease in peripheral basophil count has recently been suggested as a potential marker of poor prognosis in malignancies. This study aimed to determine the optimal cutoff value for basophil count and assess its clinicopathological and prognostic significance in esophageal squamous cell carcinoma (ESCC).
methodsWe retrospectively analyzed 194 patients with ESCC (157 men, 37 women; mean age, 67 years [range, 34-88]) who underwent curative surgery between 2010 and 2020, including 100 who received neoadjuvant chemotherapy. Receiver-operating characteristic curve analysis identified an optimal basophil cutoff value of 17.4/μL. Patients were divided into low- and high-basophil groups, and clinicopathological factors and prognosis were assessed using univariate and multivariate analyses.
resultsLow-basophil counts were significantly correlated with low neutrophil counts but not with C-reactive protein level. Multivariate analysis to predict overall survival identified deep invasion, elevated C-reactive protein, and low-basophil count as independent predictors of a poor prognosis (P <0.05).
conclusionLow preoperative basophil count is an independent adverse prognostic factor in ESCC. As basophil count was not correlated with C-reactive protein, it may provide prognostic value beyond conventional inflammation-based markers and could represent a simple, low-cost biomarker to aid risk stratification in the preoperative setting.
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